Academia Sinica

Keng-Hui Lin

Chen-Chie Wang

Yen-Liang Liu

Narayan Mishra

Yi-Hsuan Lee

Cheng-Kuang Huang

A microwell device and a method of manufacturing the same are provided. The microwell device includes a substrate and a plurality of microwells formed on the substrate. In addition, each of the microwells includes a cavity being recessed on the substrate and an opening, and the diameter of the opening is smaller than the largest inner diameter of the cavity. Furthermore, the microwells are curved.

Microwell device and method of manufacturing the same

A fabricating device of a three-dimensional (3-D) scaffold comprises a bubble generator, a bubble mixing channel, a coagulating solution channel and a bubble collector. The bubble generator includes a gas channel and a gel solution channel crossing the gas channel. The bubble mixing channel is connected with a first outlet of the bubble generator. The coagulating solution channel is connected with the bubble mixing channel. The bubble collector is connected with a second outlet of the bubble mixing channel.

Fabricating device of three-dimensional scaffold and fabricating method thereof

Methods and apparatuses for using microfluidics to generate bubbles and using the generated bubbles to construct scaffolds and cell-holding structures for culturing biological samples or analytes. In one implementation, a scaffold for growing cells is provided to include a matrix of interconnected cavities formed from mixing a gas and a liquid containing a cross linkable material to produce a matrix of gas bubbles of substantially the same size and cross linking the cross linkable material to form a structure in which cells are grown. In another implementation, a scaffold apparatus for growing cells includes a ball of a cross linked material forming an exterior shell that encloses to form a hollow interior inside the ball and biological samples embedded in the external shell.

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Taipei, Taiwan

Keng-Hui Lin