Mayo Foundation for Medical Education and Research

University of Memphis Research Foundation

Industry-University Cooperation Foundation Hanyang University

Kendall H Lee

Kevin E Bennet

Christopher John Kimble

Kip A Ludwig

Stephan J Goerss

Anders J Asp

Igor A Lavrov

Riazul Islam

Evan N Nicolai

Dong-Pyo Jang

Inyong Kim

Charles D Blaha

Kristin D Zhao

Megan L Gill

Peter J Grahn

Yoonbae Oh

Epidural electrical stimulation (EES) systems and techniques for accessing and locating targeted spinal cord segments are disclosed. In some examples, a method includes providing a first set of electrodes of an EES system at a first set of locations on the dura mater of a spine of a mammal, the first set of locations on the dura mater corresponding to a first muscle group of the mammal; providing a second set of electrodes of the epidural electrical stimulation system at a second set of locations on the dura mater of the spine of the mammal, the second set of locations on the dura mater corresponding to a second muscle group of the mammal; and stimulating the first and second sets of locations on the dura mater by electrically energizing the first and second sets of electrodes, respectively, thereby activating the first and second muscle groups in a coordinated manner.

Epidural stimulation and spinal structure locating techniques

A surgical system includes a skull attachment device that includes a support base configured to seat against a skull of a patient and one or more pins extending from a bottom surface of the support base and configured to pierce the scalp to seat the skull attachment device against the skull. The surgical system also includes an interface disposed along a top surface of the support base and having a shape that compliments a profile of a mating feature of a stereotactic device for defining a position and an orientation of the stereotactic device with respect to the support base while the interface is engaged with the mating feature.

Neurosurgical systems and related methods

This document provides methods and materials involved in detecting and delivering neurochemical signals, electrophysiological signals, ions, or combinations thereof within a mammal. For example, systems that can include one or more implantable devices containing probes configured to detect neurochemical signals (e.g., neurotransmitter concentrations), electrical signals, ions, or combinations thereof and one or more implantable devices containing electrodes and/or microfluidic delivery components configured to deliver neurochemical signals (e.g., neurotransmitters), electrical signals, ions, or combinations thereof to one or more locations within a mammal are provided.

Feedback loop for stimulating nerve tissue downstream of a damaged or severed nerve

Techniques are described for determining a voltammogram that characterizes a result of a fast-scan cyclic voltammetry process. The FSCV process can be performed using a sensing apparatus at least partially immersed in a volume of blood of a mammal. A system can process the voltammogram to determine a concentration of a neurochemical in the volume of blood of the mammal.

Voltammetric neurochemical detection in whole blood

This document provides methods and materials involved in assessing concentrations of analytes in an environment using a diamond-containing carbon electrode. For example, methods and materials for using FSCV or paired pulse voltammetry to discriminate analytes based on their adsorption characteristics to a diamond-containing carbon electrode are described herein.

Diamond-containing electrodes for neurochemical detection

Systems for the detection and delivery of neurochemical and electrical signals for functional restoration

This document provides methods and materials involved in differentiating analytes detected using a FSCV method. For example, methods and materials for using paired pulse voltammetry to discriminate analytes based on their adsorption characteristics to an electrode (e.g., a carbon fiber electrode) are provided.

Differentiating analytes detected using fast scan cyclic voltammetry

This document relates to methods and materials involved in detecting neurochemical signals, electrophysiological signals, ions, or combinations thereof with brain tissue. For example, methods and materials for using probes to detect neurochemical signals (e.g., neurotransmitter concentrations), electrical signals, or combinations thereof during deep brain stimulation are provided.

Growing community of inventors

Rochester, MN, United States of America

Kendall H Lee