The State University of New York

Ken-Tye Yong

Paras Nath Prasad

Earl Jim Bergey

Indrajit Roy

Supriya Mahajan

Adela Bonoiu

Stanley A Schwartz

Provided are methods and compositions for inhibiting expression of one or more target genes. The compositions contain RNA polynucleotides that can inhibit expression of a target gene via RNA interference (RNAi) electrostatically complexed with surface functionalized gold nanorods (GNRs). The RNA polynucleotides are not covalently bound to the surface functionalized GNRs. The method involves inhibiting expression of a target gene in an individual. The method is performed by administering to the individual an effective amount of a composition containing surface functionalized GNRs electrostatically complexed with RNA polynucleotides, such as siRNA, that can inhibit expression of the target gene via RNAi. The siRNA is not covalently bound to the surface functionalized GNRs.

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Tonawanda, NY, United States of America

Ken-Tye Yong