Aventis Pasteur Limited

Other

Ken Sasaki

Michel Henri Klein

Sheena M Loosmore

Robin E Harkness

Pele Chong

Yan-Ping Yang

Michel H Klein

An isolated and purified outer membrane protein of a Moraxella strain, particularly , having a molecular mass of about 200 kDa, is provided. The about 200 kDa outer membrane protein as well as nucleic acid molecules encoding the same are useful in diagnostic applications and immunogenic compositions, particularly for in vivo administration to a host to confer protection against disease caused by a bacterial pathogen that produces the about 200 kDa outer membrane protein or produces a protein capable of inducing antibodies in a host specifically reactive with the about 200 kDa outer membrane protein.

High molecular weight major outer membrane protein of moraxella

An isolated and purified outer membrane protein of a Moraxella strain, particularly , has a molecular mass of about 200 kDa. The about 200 kDa outer membrane protein as well as nucleic acid molecules encoding the same are useful in diagnostic applications and immunogenic compositions, particularly for in vivo administration to a host to confer protection against disease caused by a bacterial pathogen that produces the about 200 kDa outer membrane protein or produces a protein capable of inducing antibodies in a host specifically reactive with the about 200 kDa outer membrane protein.

An isolated and purified outer membrane protein of a Moraxella strain, particularly having a molecular mass of about 200 kDa, is provided. The about 200 kDa outer membrane protein as well as nucleic acid molecules encoding the same are useful in diagnostic applications and immunogenic compositions, particularly for in vivo administration to a host to confer protection against disease caused by a bacterial pathogen that produces the about 200 kDa outer membrane protein or produces a protein capable of inducing antibodies in a host specifically reactive with the about 200 kDa outer membrane protein.

A multi-valent immunogenic composition confers protection on an immunized host against infection caused by both and . Such composition comprises at least four antigens comprising at least one antigen from , and at least one antigen from . Three of the antigens are adhesins. High molecular weight (HMW) proteins and adhesin (Hia) proteins of non-typeable Haemophilus and a 200 kDa outer membrane protein of comprise the adhesin components while the other antigen is a non-proteolytic analog of Hin47 protein. Each component does not impair the immunogenicity of the others. The multi-valent immunogenic composition may be combined with DTP component vaccines, which may also include non-virulent poliovirus and PRP-T, to provide a component vaccine without impairment of the immunogenic properties of the other antigens.

Multi-component vaccine to protect against disease caused by Haemophilus influenzae and Moraxella catarrhalis

An isolated and purified outer membrane protein of a Moraxella strain, particularly M. catarrhalis, has a molecular mass of about 200 kDa. The about 200 kDa outer membrane protein as well as nucleic acid molecules encoding the same are useful in diagnostic applications and immunogenic compositions, particularly for in vivo administration to a host to confer protection against disease caused by a bacterial pathogen that produces the about 200 kDa outer membrane protein or produces a protein capable of inducing antibodies in a host specifically reactive with the about 200 kDa outer membrane protein.

Growing community of inventors

Willowdale, Canada

Ken Sasaki