Sony Corporation

Kabushiki Kaisha Toshiba

National Institutes of Biomedical Innovation, Health and Nutrition

Daiichi Sankyo Company, Limited

Toshiba Digital Solutions Corporation

Other

Kyocera Corporation

Mitsubishi Heavy Industries Limited

University of Pennsylvania

Osaka University

Mitsubishi Hitachi Power Systems, Ltd.

Keio University

Mitsubishi Heavy Industries Compressor Corporation

Kyoto Pharmaceutical Industries, Ltd.

Meiji University

Ken Ishii

Yasushi Fujinami

Kenichi Nakanishi

Naohiro Adachi

Hideaki Okubo

Tatsuo Shinbashi

Keiichi Tsutsui

Hiroyuki Iwaki

Ryoji Ikegaya

Takashi Nakao

Yukihiro Ushiku

Shuichi Samata

Kouji Kobiyama

Makoto Koizumi

Jun Takahashi

Yuji Kasuya

Junji Ito

Takahiro Ota

Yoshiaki Toyama

Takako Niwa

Morio Matsumoto

Tetsuya Yamamoto

Michio Yamaji

Hideki Ito

Kei Sakamoto

Tsuneyuki Okabe

Hiroharu Oyama

Hiroshi Akahori

Donald L Siegel

Tsunenori Shiimoto

Haruhiko Terada

Nobuyori Yagi

Daisuke Ogura

Atsushi Kawasaki

Lui Sakai

Shizuo Akira

Ena Ishii

Takeo Furuhata

Kazutoshi Yokoo

Yasuyuki Fujiya

Aimee S Payne

Atsushi Sugai

Yuji Kawano

Takumi Matsumura

Hidetaka Haraguchi

Kohei Hatano

Yujiro Watanabe

Motonari Machida

Toshihiro Tsukui

Toshihiro Horii

Taiki Aoshi

Hitoshi Kobayashi

Masaki Atarashi

Masaharu Inui

Mamoru Aizawa

Masaki Miyazaki

Fumihiro Okada

Rieko Takano

Takahiro Tougan

Keisuke Kamitani

Fumitaka Fujita

Cevayir Coban

Fumihiko Takeshita

Takashi Kusakabe

Tomohiro Kanuma

Etsushi Kuroda

Burcu Temizoz

John R Stanley

Kazunori Hashimoto

Akifumi Ohno

Yoshihiro Ogura

Junya Kawai

Hideaki Sato

Tadatoshi Ishii

Kazuki Yamamoto

Kentarou Mori

Shion Itou

Tomoyuki Hoshikawa

Haruki Funao

Masayuki Omiya

Jun Yamagami

Kazuhiro Gotou

Masashi Uemoto

Daichi Soshi

Hirokazu Ikeyama

Yousuke Ujihara

Yuto Akimoto

Hiroki Takenouchi

Satoru Iwahashi

Toshiyuki Morishita

Masafumi Ofuku

Shunsuke Takashima

Wakana Yokozeki

Masaya Fujii

Masafumi Ando

Teppei Fujimoto

Kazuya Otake

Manami Toriyama

According to an embodiment, a determination apparatus for determining congestion of persons includes a first database, a stay information acquisition unit, and a first determination unit. The database stores position information indicative of a position of a person together with time information, in association with identification information of the person. The acquisition unit acquires information on one or more persons who have made a stay and to acquire, for each of the one or more persons who have made a stay, information on a time slot during which the stay was made, based on the position information and the time information stored in the first database in association with the identification information of the each of the one or more persons. The determination unit determines that an area in which multiple people have stayed for a predetermined continuous time length or more is a congested area.

Determination apparatus, determination method, and program

The present invention provides the induction of novel Th1 response, the induction of cytotoxic T cells and anti-cancer/anti-allergic activity techniques. Provided is a combination of a CpG oligonucleotide and an STING agonist. Also provided is a composition which contains an STING agonist, can be used as a type-I adjuvant, and is characterized in that the STING agonist is administered together with a CpG oligonucleotide. Further provided is an anti-cancer agent comprising a CpG oligonucleotide and is characterized in that the CpG oligonucleotide is administered together with an STING agonist. Still further provided is a composition which contains a CpG oligonucleotide and can be used for reducing or eliminating the IgE-inducing activity of an STING agonist.

Th1-inducing adjuvant comprising combination of different nucleic acid adjuvants and use of same

The present invention aims to provide a medicament capable of treating and/or preventing diseases associated with oxidative stress by inhibiting the protein-protein interaction between Keap1 and Nrf2 and activating Nrf2. The present invention relates to a compound represented by the following formula (1): wherein each symbol is as described in the DESCRIPTION, or a pharmaceutically acceptable salt thereof. In addition, the present invention also relates to a medicament containing the aforementioned compound, for the prophylaxis and/or treatment of diseases involving oxidative stress selected from the group consisting of chronic kidney disease, non-alcoholic steatohepatitis, chronic obstructive pulmonary disease, radiation skin disorder, radiation mucosal disorder, cardiac failure, pulmonary arterial hypertension, Parkinson's disease, Friedreich's ataxia, multiple sclerosis, age-related macular degeneration, retinitis pigmentosa and glaucoma.

Benzotriazole compound

In order to further increase antigenicity to provide a DNA vaccine which is clinically usable in humans, the inventors of the present invention focused on exosomes, which are garnering attention as tools for DDS, and discovered that an exosome expressing a fusion antigen of an exosome (extracellular microparticle)-constituent protein and a vaccine antigen has excellent cytotoxic T-cell inducibility. Consequently, the present invention provides a nucleic acid constituent including a nucleic acid sequence coding for an exosome marker protein and a nucleic acid sequence coding for a vaccine antigen.

Exosome-targeted DNA vaccine

Provided is a method whereby an objective indicator of an immune-related disease can be rapidly and easily detected, the method comprising detecting, as an indicator of an immune-related disease, a difference in the result of observing a primary cilium of an immune-related cell between a subject specimen and a normal specimen.

Method for detecting indicator of immune-related disease

A work content analyzing apparatus of the present embodiment includes a first database storing state information indicating a state of each of one or a plurality of workers in association with time information and identification information of the worker, an estimation unit estimating the work content executed by the worker on the basis of at least two pieces of state information associated with same time in the state information stored in the first database, a specification unit specifying work time spent for the estimated work content on the basis of the state information stored in the first database and the time information associated with the state information, and an analysis unit analyzing the work content on the basis of the estimated work content and the specified work time.

Work content analyzing apparatus, work content analyzing method, program, and sensor

Provided are non-aggregating immunostimulatory oligonucleotides. The present invention also provides a delivery agent for an immunostimulatory-oligonucleotide nucleic acid medicine, said delivery agent including a nucleic acid that contains a phosphorothioated nucleotide. According to another aspect, the present invention further provides an oligonucleotide including a bioactive core, and a nucleic acid that contains a phosphorothioated nucleotide. The present invention yet further provides an immunostimulator including the bioactive core of a type A/D, type B/K, or type C immunostimulatory oligonucleotide.

Non-aggregating immunostimulatory oligonucleotides

The write time is to be shortened in a storage device using memories that require different write times from each other, such as nonvolatile memories. In a memory controller including a plurality of write request holding units and a selection unit, the write request holding units holds a write request with respect to each of a plurality of memory modules that require different write times from one another. The selection unit selects one of the plurality of write request holding units in accordance with memory state information indicating whether each of the plurality of memory modules is in a busy state, and causes outputting of the write request.

Memory controller, storage device, information processing system, and memory control method

Provided is a method for bonding dissimilar metals to each other, the method comprising: dissimilar metal layer-forming steps (P), (P), (P) for supplying, to form dissimilar metal layers; a second metal layer-forming step (P) for supplying, on the surface of the dissimilar metal layers, a filler material formed of a second metal, and heating the filler material formed of the second metal to a temperature equal to or higher than a melting point of the second metal, to form a second metal layer formed of the second metal; and a second material-to-be-bonded welding step (P) for welding a second material to be bonded that is formed of the second metal, onto the second metal layer.

Method for bonding dissimilar metals to each other

TH1-inducing adjuvant comprising combination of different nucleic acid adjuvants, and use of same

The order of read access to a memory is appropriately determined. A memory system includes a plurality of memories and a memory controller. The memory controller includes a memory write control unit and a memory read control unit. The memory write control unit generates a write request for any one of the plurality of memories on the basis of a write command from a computer. The memory read control unit generates a read request for any one of the plurality of memories according to priority corresponding to a data processing state of write data related to the write request in the memory write control unit on the basis of a read command from the computer.

Memory controller, memory system, and information processing system

The present invention provides an oligodeoxynucleotide containing humanized K type CpG oligodeoxynucleotide and poly deoxyadenylate, wherein the poly deoxyadenylate is placed on the 3'-side of the humanized K type CpG oligodeoxynucleotide. In addition, the present invention provides a complex containing the aforementioned oligodeoxynucleotide and &#x3b2;-1,3-glucan.

Complex containing oligonucleotide having immunopotentiating activity and use thereof

A vehicle-mounted gateway apparatus according to an embodiment includes a communication device including an external communication interface for connection to the network outside the mobile body with each of a plurality of different external communication schemes and an internal communication interface for connection to each of the plurality of data sources within the mobile body; and a control device configured to transmit data collected from each of the data sources through the internal communication interface to the network outside the mobile body. The control device includes a communication channel selection section configured to select a communication channel from the plurality of external communication schemes for each of the data sources, and a monitoring control section configured to monitor data output from each of the data sources and to transmit the data to the network outside the mobile body over a selected one of the communication channels associated with the data source. The communication channel selection section is configured to switch between the communication channels associated with each of the data sources depending on a communication connection state of each of the plurality of external communication schemes based on priority setting in which the plurality of external communication schemes are arranged in a predetermined priority order.

Vehicle-mounted gateway apparatus and vehicle mounted gateway system

A data holding characteristic of a memory cell is improved in a memory system in which data is encoded and written to a memory cell. A first candidate parity generation unit generates, as a first candidate parity, a parity for detecting an error in an information section in which a predetermined value is assigned in a predetermined variable area. A second candidate parity generation unit generates, as a second candidate parity, a parity for detecting an error in the information section in which a value different from the predetermined value is assigned in the predetermined variable area. A selection unit selects a parity that satisfies a predetermined condition from among the first and second candidate parities as a selection parity. An output unit outputs a codeword constituted by the information section corresponding to the selection parity and the selection parity.

Encoding device, memory controller, communication system, and encoding method

Growing community of inventors

Tokyo, Japan

Ken Ishii