Matsushita Electric Industrial Co., Ltd.

Astellas Pharma Gmbh

Yamanouchi Pharmaceutical Company Ltd.

Mitsui Petrochemical Industries, Ltd.

Mitsubishi Pharma Corporation

Mitsui Pharmaceuticals, Inc.

Sam Research Corporation

Ken Ikeda

Makoto Takeuchi

Masahiko Hayakawa

Ryobun Tachita

Junji Sato

Kenichi Takahashi

Mari Abe Fukuda

Yasuo Isomura

Yasuhiro Yonetoku

Yoshinori Okamoto

Minako Takeishi

Masakatsu Kawakami

Ryo Naito

Yoshihiro Keto

Yasuo Iwasaki

Akira Awaya

Noriaki Kihara

Kazutoshi Horikomi

Ikuo Tomino

Akira Mizuchi

Akihisa Kawasaki

Takumi Kitahara

Masao Kinoshita

Tadayuki Sasaki

Kiyohiro Samizu

Tomoko Kobayashi

Masaharu Ishiguro

Akio Teranishi

Hiroshi Uebayashi

Yasunari Kimura

Yuichiro Kokubun

Izumi Sato

Nozomu Tagaya

Toshiya Shiojima

Administration of 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-1,3-thiazole-5-carboxylic acid is effective for treating a stomach or small intestine ulcer.

Treatment of a stomach or small intestine ulcer with 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-1,3-thiazole-5-carboxylic acid

A method for treating a digestive ulcer of the small intestine or stomach is disclosed with a non-purine xanthine oxidase inhibitor that is a carboxylic acid compound, wherein the non-purine xanthine oxidase inhibitor is a carboxylic acid compound of formula (I) or its salt and wherein the terms of formula (I) are herein defined: 

Methods for treating an ulcer of the small intestine and stomach

A depressant of capsaicin-sensitive sensory nerve, containing quinuclidin-3'-yl 1-phenyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylate or a salt thereof as an active ingredient, specifically a therapeutic drug of interstitial cystitis, hypersensitive disorder of the lower urinary tract, and/or abacterial prostatitis.

Pharmaceutical composition for therapy of interstitial cystitis

The service presentation apparatus includes a member database () for storing the information of members registered preliminarily as users, basic authentication means () for authenticating official members through an open information communication line (), and mobile communication authentication means () for executing the authentication by way of the mobile communication terminal () preliminarily registered in the member database (), while the user side includes a service terminal () connected to a server () through the open information communication line (). In this configuration, an individual authentication system of higher accuracy will be realized. Moreover, a highly reliable accounting system is realized by applying the individual authentication system.

Individual authentication method, individual authentication apparatus, accounting method, accounting apparatus

There is provided an acid addition salt of (&#x2212;)-(3R)-quinuclidin-3-yl(1R)-1-phenyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylate with an acid selected from the group consisting of (&#x2212;)-(2S,3S)-tartaric acid, (+)-(2S,3S)-di-O-benzoyltartaric acid, (+)-(2S,3S)-di-O-(4-methylbenzoyl)tartaric acid, (&#x2212;)-L-phenylalanine, benzenesulfonic acid, cyclohexanesulfamic acid, hydrobromic acid, naphthalene-2-sulfonic acid, sebacic acid, (+)-camphor-10-sulfonic acid, p-toluenesulfonic acid, ethanesulfonic acid, methanesulfonic acid and methyl phosphate, which has little hygroscopicity that affects the use as a drug or its drug substance, and is very useful as a drug or its drug substance.

Salts of quinuclidine derivative

An object of the present invention is to provide a novel medicament with which motor neuron diseases can be treated. According to the present invention, there is provided a therapeutic agent for motor neuron diseases which comprises 3-methyl-1-phenyl-2-pirazoline-5-on or physiologically acceptable salts thereof as an active ingredient.

Therapeutic agent for amyotrophic lateral sclerosis (ALS)

Quinuclidine derivatives represented by general following general formula (I), salts, N-oxides or quaternary ammonium salts thereof, and medicinal compositions containing the same.

Quinuclidine derivatives and medicinal composition thereof

The present invention relates to an novel anti-motoneuron-disease agent, comprising superoxide dismutase conjugated with lecithin through chemical crosslinking represented in the following generic formula (PC-SOD) as an effective ingredient:

Anti-motoneuron-disease agent

A clock signal generator produces a basic clock signal. A variable delay device is operative for delaying the basic clock signal by an adjustable interval and thereby converting the basic clock signal into a delay-resultant clock signal. A pseudo-noise code is generated at a timing depending on the delay-resultant clock signal. A spread-spectrum information signal is despread into a non-spread information signal in response to the pseudo-noise code. A correlator detects a correlation between the spread-spectrum information signal and the pseudo-noise code. The adjustable interval provided by the variable delay device is controlled in response to the detected correlation to provide synchronization between the spread-spectrum information signal and the pseudo-noise code.

Direct-sequence spread-spectrum communication system

A wireless data communication system comprises: base stations located to have cells arranged equidistantly therebetween; mobile units, each being located within either of the cells, each of the base stations communicating with mobile units within its cell through plural channels provided by FDM. In the system, each of the base station may comprise a detector for monitoring the channels and detecting a free channel, and a transmission portion for continuously transmitting a signal including data indicative of the detected free channel. In the system, the plurality of channels used in one of cells have given frequency bands respectively which are the same as given frequency bands in other cells. In the system, each of the mobile stations may comprise a chip synchronizing circuit for effecting chip synchronizing between the each of the mobile stations and its base station. In that system, a mobile unit having an antenna whose directivity is controllable, measures distances to determine a direction to its base station with measured distances and received distance from other mobile unit. In that system, a channel with an interference is detected and inhibited to be used and data indicative of the channel with the interference may be stored in a memory and the absence of the interference may be detected and the memory is renewed.

Wireless data communication system

In a position measuring system, a position of a moving body is derived when data is sufficient for such derivation. On the other hand, when data is insufficient for such derivation, an area which may include the position of the moving body is derived. Accordingly, a user correctly evaluates reliability of information which is displayed. In a position measuring method, a measurement error of the derived position is evaluated. Further, a moving error evaluation is performed to evaluate an increase of the error. By changing the measurement error of the derived position, the area which includes the position of the moving body with high reliability can be displayed to the user.

Position measuring system and method therefor

Pyrimidine compound and pharmaceutically acceptable salts thereof

A method, for use in a receiver for the NAVSTAR global positioning system (GPS), of deriving successive values of phase of a received pseudo-random code signal following a momentary interruption of satellite signal reception, with the effects of signal noise eliminated by averaging processing, by first setting a replica pseudo-random code signal to an initial phase value which provides high correlation with the received code signal, and thereafter periodically executing phase derivation operations to obtain the phase of the received code signal, by obtaining the phase difference between the received and replica code signals, obtaining the average value of all of such phase differences obtained up to that point since the initial phase derivation operation, and adding that average value to the sum of a phase value obtained in the first phase derivation operation and a total estimated amount of change of phase of the received code since that first operation. The estimated phase change is obtained based on a corresponding amount of frequency change that has occurred in the carrier of the received signal.

Method of deriving phase of pseudo-random code signal in global

A GPS receiver comprising a pseudonoise generator for simultaneously generating pseudonoise signals respectively corresponding to satellite electromagnetic waves transmitted from two or more satellites, an oscillator for simultaneously regenerating carrier waves of the plurality of satellite electromagnetic waves, and a plurality of demodulators responsive to the regenerated carrier waves and the pseudonoise signals to demodulate individual satellite electromagnetic waves independently, to thereby regenerate data transmitted from individual satellites, each demodulator being operative, during demodulation, to detect a set of phases of one pseudonoise signal and one regenerated carrier wave relative to one satellite electromagnetic wave on time division basis and including a first mixer for mixing of one pseudonoise signal, a second mixer for mixing of one regenerated carrier wave and a filter, whereby a set of phases of one pseudonoise signal and one regenerated carrier wave is changed to another set at timed relationship with transmission of data from individual satellites to measure a phase of one pseudonoise signal relative to one satellite electromagnetic wave, thereby tracking data transmitted from individual satellites on the basis of the measured phase.

GPS receiver

Growing community of inventors

Tokyo, Japan

Ken Ikeda