Yamanouchi Pharmaceutical Company Ltd.

Ken-ichiro Sakamoto

Akihiro Tanaka

Hiroyuki Koshio

Akira Matsuhisa

Takeyuki Yatsu

Nobuaki Taniguchi

Atsuki Yamazaki

This invention relates to nitrogen-containing aromatic 5-membered ring-condensed benzazepine derivatives represented by the general formula (I) ##STR1## (symbols in the formula have the following meanings; ring B: a nitrogen-containing aromatic 5-membered ring having at least 1 nitrogen atom and optionally one oxygen or sulfur atom, which may optionally have substituent(s), R.sup.1 and R.sup.2 : these may be the same or different from each other and each represents a hydrogen atom, a halogen atom, a lower alkyl group, an amino group which may optionally be substituted by lower alkyl group(s), or a lower alkoxy group,

Condensed benzazepine derivative and pharmaceutical composition thereof

Benzazepine derivatives represented by the following general formula (I) useful as arginine vasopressin antagonists or pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and difluorobenzazepinone derivatives represented by the following general formulae (II) and (III) which are useful as production intermediates of the compound (I). ##STR1##

Benzazepine derivative, pharmaceutical composition thereof, and

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Ibaraki, Japan

Ken-ichiro Sakamoto