Mitsubishi Chemical Corporation

Ken-ichi Saito

Tomoko Bessho

Showbu Sato

Kazutomo Imahori

Akihiko Takashima

Toshimitsu Hoshino

Akiko Shiratsuchi

Akihiro Tobe

Yasuhiro Morinaka

Mamoru Sugano

Haruyuki Chaki

Kunihiro Ninomiya, Deceased

Haruko Harada

Kazutoshi Watanabe

Ryoichi Ando

Tetsuo Jikihara

Mitsuo Egawa

Aya Shoda

Naoko Ando

Tomoko Yugami

Michikazu Abe

Satoshi Yuki

Rie Kawamoto

A pyrimidone derivative represented by the formula (I) or a salts thereof: wherein Rrepresents an alkyl group, an alkenyl group, an alkynyl group, a cycloalkyl group, an aryl group and the like; Rrepresents a hydrogen atom, hydroxyl group, an alkyl group, an alkenyl group and the like, Rrepresents a pyridyl group, and a medicament comprising said derivative or a salt thereof as an active ingredient which is used for preventive and/or therapeutic treatment of a disease caused by tau protein kinase 1 hyperactivity such as Alzheimer disease.

Pyrimidone derivatives

Medicament for treatment of irritable bowel syndrome

Sialic acid derivatives represented by the following general formula:

Sialic acid derivatives

A preventive or therapeutic agent for Alzheimer's disease which comprises a substance exhibiting an inhibitory action to tau-protein kinase I as an effective component is provided. A pharmaceutical composition comprising said agent and a method of inhibiting neuronal cell death in the brain are also provided.

Gene encoding human tau-protein kinase I and use thereof

Screening method for therapeutic agents against Alzheimer's disease

Remedy and preventive for nervous system disorders

A novel 4-acylaminopyridine derivative represented by the following formula (I) is disclosed. ##STR1## The 4-acylaminopyridine derivative of the present invention is useful as a medicine for treating disturbances of memory such as senile dementia and Alzheimer's disease, since it has an action of directly activating malfunctioned cholinergic neuron.

4-Acylaminopyridine derivative

Preventive or therapeutic agents for alzheimers disease a screening

4-acylaminopyridine derivative

Growing community of inventors

Kanagawa, Japan

Ken-ichi Saito