Kyoto Yakuhin Kogyo Kabushiki Kaisha

Kyoto Pharmaceutical Industries, Ltd.

The Green Cross Corporation

Ken-ichi Nishimura

Kazuhiko Kitao

Nobuharu Kakeya

Masayasu Kasai

Akihisa Yoshimi

Masahiro Kikuchi

Koichi Yamanouchi

Takeshi Uchida

Susumu Nishizawa

Nobuo Kondoh

Takayoshi Mori

Satoru Hatano

Hiroyuki Muro

Pharmaceutical preparation containing prostaglandin compound for rectal

Cephalosporin compounds

Fatty acids having 8 to 14 carbon atoms, leucinic acid and nontoxic salts thereof promote the absorption of a pharmacologically-active substance through the rectum into the blood stream and effectively raise the concentration of such active substance in the blood stream even when said active substance is one which is usually absorbable through the rectum only with considerable difficulty.

Adjuvant for promoting absorption of pharmacologically active substances

Compounds satisfying four specific requirements, namely: (1) a log P value in the range of from 2.5 to 6, (2) a molecular structure with at least one carboxyl group, (3) a pKa value for the carboxyl group of not less than 2.5 and (4) absence of halo substitution, and nontoxic salts thereof promote absorption of pharmacologically-active substance through the rectum into the bloodstream and are effective to raise the concentration of such active substance in the bloodstream even when the active substance is usually unabsorbable or absorbable through the rectum only with considerable difficulty. The compounds are combined with pharmacologically-active ingredients, with pharmaceutical bases suitable for rectal administration of drugs and with appropriate combinations of both.

Absorption-promoting compounds, compositions thereof with

Growing community of inventors

Kyoto, Japan

Ken-ichi Nishimura