Takeda Chemical Industries, Inc.

Takeda Limited Industries, Ltd.

Ken-ichi Kuroshima

Tsutomu Kurokawa

Mitsuru Shiraishi

Masanori Baba

Naoyuki Kanzaki

Osamu Nishimura

Tsunehiko Fukuda

Kazuo Nakahama

Yoshio Aramaki

Hidekazu Sawada

Sumie Yoshitomi

Chisako Seko

This invention is to provide a pharmaceutical composition for antagonizing CCR5 which comprises a compound of the formula:

Pharmaceutical composition for antagonizing CCR5 comprising anilide derivative

Disclosed are (A) an antibody to a peptide consisting of 8 to 9, or 12 to 14 successive amino acids from a polypeptide having nerve growth factor-like activity, (B) a method for producing the antibody, (C) a cloned hybridoma which produces the antibody, (D) a method for producing the cloned hybridoma, (E) a conjugate of the above mentioned peptide with a carrier protein, and (F) a method for purifying, and a method for detecting and assaying a polypeptide having nerve growth factor-like activity.

Antibodies to peptides having NGF-like activity, and use thereof

Disclosed are (A) an antibody to a peptide including at least 8 successive amino acids of an amino acid sequence represented by formula

Antibodies to peptides having NGF-like activity, said antibodies having

The present invention relates to a glia activating factor (GAF) in which 33 to 49 N-terminal amino acids are deleted from the N-terminus of the GAF polypeptide of SEQ ID NO: 3, as well as an anti-GAF antibody which is highly sensitive to assay the GAF and is capable of neutralizing GAF's activity, is produced. Using the antibody, GAF and its biological activity can be assayed easily with high sensitivity. Further, the neutralizing antibody can be expected to have preventive and curative effects on diseases caused by GAF's excessive action. Furthermore, the GAF polypeptide disclosed herein is more stable to acids and heat than the conventional GAFs, therefore, it can be used as a platelet-increasing agent, etc., more advantageously than the previously known GAFs.

Modified GAF polypeptides

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Osaka, Japan

Ken-ichi Kuroshima