Tokyo Medical and Dental University

Fujifilm Corporation

Ken-ichi Kozaki

Johji Inazawa

Issei Imoto

Jun Inoue

Tatsuyuki Kawano

Shinsuke Yamamoto

Hitoshi Tsuda

Shuhei Komatsu

The present inventors have found microRNAs which are strongly associated with stabilization of NRF2 in tumors, and an object of the present invention is to provide means for utilizing such miRNAs for the diagnosis and treatment of cancer. The inventors conducted screening of 470 microRNAs in a microRNA library by use of HeLa cells. As a result, 8 miRNAs each exhibiting a large decrease in miRNA activity as compared with a control miRNA, and 8 miRNAs each exhibiting a large increase in miRNA activity as compared with a control miRNA, were identified. The inventors have found that the NRF2 activation in the living body, in particular tumor cells, can be detected by use of the thus-identified miRNAs, whereby malignancy of a tumor, or the like can be differentiated. The inventors have also found that a nucleic acid including a miRNA sequence associated with reduction in the aforementioned ARE activity can be used as a cancer therapeutic agent.

Method for assaying MicroRNA, cancer therapeutic agent, and medical composition containing same for cancer therapy

Method for assaying microRNA, cancer therapeutic agent, and medicinal composition containing same for cancer therapy

An object of the present invention is to provide a method for detecting cancer and an agent for suppressing cell growth by identification of genes showing behaviors characteristic in cancer such as esophageal carcinoma. The present invention provides a method for detecting cancer, which comprises detecting canceration through detection of amplification of at least one gene existing in an 1q32-1q41 chromosomal region in a specimen.

Method for detecting esophageal carcinoma and agent for suppressing esophageal carcinoma

The present invention is directed to methods for suppressing the growth of oral squamous-cell carcinoma cells. The methods include introducing at least one gene selected from miR-137 or miR-193a into oral squamous-cell carcinoma cells.

Method for detecting carcinoma and agent for suppressing carcinoma

Growing community of inventors

Tokyo, Japan

Ken-ichi Kozaki