Mochida Pharmaceutical Co., Ltd.

Ken-ichi Amano

Tsutomu Satoh

Yoshitaka Maeda

Yasushige Akada

Tomoyuki Kamino

Naoto Kosuga

Daido Hotta

Hideharu Uchida

A compound represented by formula (I'): (wherein m, n, and p each represent 0 to 2; q represents 0 or 1; Rrepresents halogen, a hydrocarbon group, a heterocyclic group, an alkoxy group, an alkoxycarbonyl group, a sulfamoyl group, a CN group, an NOgroup, or the like; Rrepresents halogen, amino, a hydrocarbon group, an aromatic heterocyclic group, or an oxo group; Xrepresents O, &#x2014;NR&#x2014;, or &#x2014;S(O)r-; Xrepresents a methylene group, O, &#x2014;NR&#x2014;, or &#x2014;S(O)r-; Q&#x2032; represents a heteroaryl group, a heteroarylalkyl group, a substituted aryl group, or an aralkyl group; Cycle moiety represents an aryl ring or a heteroaryl ring; and the wavy line represents an E-isomer or a Z-isomer), a salt of the compound, or a solvate of the compound or the salt. A pharmaceutical composition and a transient receptor potential type I (TRPV1) receptor antagonist each contain, as an active ingredient, at least one of the compound, a salt of the compound, and a solvate of the compound or the salt.

Heterocyclidene acetamide derivative

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Shinjuku-ku, Japan

Ken-ichi Amano