Oxford Nanopore Technologies Limited

Ken Healy

James Anthony Clarke

Clive Gavin Brown

Ping Xie

Jason Robert Hyde

Gurdial Singh Sanghera

Paul Raymond Mackett

Justin Millis

Pedro Miguel Ortiz Bahamon

Jonathan Edward McKendry

Richard Kenneth John Wiltshire

Mark David Jackson

Ioana Pera

Mark Hyland

Rhodri Rhys Davies

Robert Greasty

Devices for improved nanopore sensing are described. An example device has a structure arranged to separate an analyte reservoir and an outlet chamber. An example device has a structure arranged to separate an analyte reservoir and an outlet chamber. The structure can include an array of nanopore structures, each nanopore structure comprising a passage for fluid connection through the structure between the analyte reservoir and outlet chamber. Control terminals can be arranged for applying a control signal to alter the electrical potential difference across that nanopore structure. Some embodiments include an electronic circuit configured to detect a signal from an electrical transduction element at each nanopore structure. Additional structural features and methods of operating and making the devices are described.

Nanopore sensing device, components and method of operation

Methods and apparatus for forming apertures in a solid state membrane using dielectric breakdown are provided. In one disclosed arrangement a plurality of apertures are formed. The membrane comprises a first surface area portion on one side of the membrane and a second surface area portion on the other side of the membrane. Each of a plurality of target regions comprises a recess or a fluidic passage opening out into the first or second surface area portion. The method comprises contacting all of the first surface area portion of the membrane with a first bath comprising ionic solution and all of the second surface area portion with a second bath comprising ionic solution. A voltage is applied across the membrane via first and second electrodes in respective contact with the first and second baths comprising ionic solutions to form an aperture at each of a plurality of the target regions in the membrane.

Methods and apparatus for forming apertures in a solid state membrane using dielectric breakdown

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Oxford, United Kingdom

Ken Healy