Locus Solutions Ipco, LLC

Locus Oil IP Company, LLC

Locus IP Company, LLC

Locus Agriculture IP Company, LLC

Flaask, LLC

Ken Alibek

Sean Farmer

Karthik N Karathur

Kent Adams

Tyler Dixon

Sharmistha Mazumder

Alibek Moldakozhayev

Anthony Nerris

Paul S Zorner

Yajie Chen

Andrew R Lefkowitz

Maja Milovanovic

Nicholas Callow

Blake Ott

Albina Tskhay

Samal Ibragimova

Alex Fotsch

Martin R Shumway

Jonathan Rogers

Ryan McGonagle

Don Kreager

Sergey Kravtsov

Caleb Adkins

The subject invention provides materials and methods for producing and purifying sophorolipids (SLP). More specifically, the subject invention provides materials and methods for the purification of both hydrophobic and hydrophilic SLP molecules to a purity of, for example, at least 80% by weight, preferably at least 95% by weight, without using solvents or centrifugation. Advantageously, the subject invention is suitable for industrial scale production of purified SLP for use in, for example, cleaning products and detergents, and uses safe and environmentally-friendly materials and processes.

Methods for purification of sophorolipids

The invention relates to systems and methods for effective production and use of microorganisms and/or the fermentation broth in which they are produced. Advantageously, the system is cost-effective, scalable, quick, versatile, efficacious, and helpful in reducing resistance to chemical compounds and residue that concerns consumers.

Distributed systems for the efficient production and use of microbe-based compositions

Methods are provided for enhancing the health, growth and/or sturdiness of turf grasses by applying a combination of microbes and/or their growth by-products to the turf grass roots and/or to soil. Specifically, in one embodiment, the subject invention utilizesand a strain of. The methods can further be used to improve maintenance and upkeep of natural turf grass fields used in, for example, athletics and recreation, as well as to increase the functionality and safety of these natural turf grass fields.

Methods for enhancing root strength and safety of turf grass

The subject invention provides microbe-based products, as well as their use to improve oil production and oil transmission and refining by, for example, remediating the disposable layers in oil tanks and other oil storage units. The subject invention can be used to remediate a sludge layer and/or other dissolved solid layers that form in oil storage tanks. Advantageously, the subject invention can decrease the cost of mechanical remediation of disposable layers, and aid in the recovery of more pure hydrocarbons from crude fluids.

Compositions and methods for removing sludge from oil storage tanks

The subject invention provides microbe-based products, as well as their use to improve oil production and refining efficiency by, for example, remediating the disposable layers in oil tanks and other oil storage units. In preferred embodiments, the microbe-based products comprise biochemical-producing yeast and growth by-products thereof, such as, e.g., biosurfactants. The subject invention can be used to remediate rag layer and/or other dissolved solid layers that form in water-oil emulsions. Furthermore, the subject invention can be used for remediating solid impurities, such as sand, scale, rust and clay, in produced water, flow-back, brine, and/or fracking fluids.

Remediation of rag layer and other disposable layers in oil tanks and storage equipment

The subject invention provides materials and methods for improving facial skin, hair and scalp health using cosmetic yeast-based masks. In a specific embodiment, the subject invention provides a yeast-based mask for application to the face, which can improve the health and appearance of thereof. In another specific embodiment, the subject invention provides a yeast-based mask for application to the hair and scalp, which can aid in preventing hair loss, as well as improve the health and appearance of the hair and scalp. Methods of using the yeast-based masks are also provided.

Yeast-based masks for improved skin, hair and scalp health

This invention relates to compositions and methods of microbial enhanced oil recovery using biochemical-producing microbes. In specific embodiments, the methods of the subject invention comprise applying a biosurfactant-producing bacteria and/or a growth by-product thereof to an oil-producing site. In preferred embodiments, the bacteria is a strain ofin spore form. In some embodiments, the methods further comprise applying the bacteria with a yeast fermentation product, an alkaline compound, a polymer, a non-biological surfactant, and/or one or more chelating agents. Advantageously, the subject invention can be useful for stimulating the flow of oil from a well, as well as dissolving scale present in an oil-bearing formation.

Microbial products and uses thereof to improve oil recovery

The present invention relates to compositions and methods for enhancing bioavailability of health-promoting substances, such as pharmaceuticals and nutritional supplements. The subject invention utilizes an adjuvant composition comprising one or more microbial-produced biosurfactants and/or isoforms thereof, to enhance bioavailability of health-promoting substances and to reduce the effective dosage that is required.

Compositions for enhancing bioavailability of pharmaceuticals, supplements and ingested substances

Embodiments of the present invention provide novel, low-cost fermentation systems and methods of their use. More specifically, the present invention provides biological reactor systems for fermenting a wide variety of, for example, bio level 1 microorganisms with very high cell densities. The reactor systems can be used to grow yeast, fungi and bacteria, as well as growth by-products thereof. In specific embodiments, the reactor systems are used to produce yeast-based compositions. In certain specific embodiments, the reactor systems can be used for the production ofyeast compositions.

Reactors and submerged fermentation methods for producing microbe-based products

The subject invention provides compositions comprising solvents and surfactants, as well as their use in improving oil and/or gas production. In some embodiments, the compositions comprise chemical or synthetic solvents and/or surfactants. In other embodiments, the compositions comprise biological components, such as microorganisms and/or their growth by-products. The subject invention can be used to dissolve, disperse and/or emulsify paraffin precipitates and/or deposits; prevent and/or inhibit paraffin deposition; remove rust deposits and prevent corrosion associated therewith; inhibit bacterial growth and/or biofilm formation; and to enhance oil recovery.

Compositions and methods for paraffin liquefaction and enhanced oil recovery in oil wells and associated equipment

The present invention provides compositions and methods for improving the quality of life for a subject, particularly a child, diagnosed with autism spectrum disorder (ASD). In preferred embodiments, a supplement composition comprising natural or naturally-derived ingredients is delivered to a subject in the form of a chocolate bar or other candy alongside administration of an antiviral medication. Advantageously, the composition and methods can improve the immune health of the subject, along with other signs and symptoms associated with ASD, infections and other immunocompromising conditions.

Compositions and methods for diagnosing susceptibility to autism spectrum disorder (ASD), reducing the likelihood of developing ASD, and/or treating ASD

The subject invention provides microbe-based products, as well as their use, for enhancing aquaculture. In particular, the subject invention provides materials and methods for producing healthy and high quality farmed fish by applying yeast and/or bio surfactant-based compositions to a fish farm. In one embodiment, the subject invention improves the environment in which the fish are farmed. In another embodiment, the subject invention provides a highly nutritious fish feed, as well as methods of feeding fish at low cost.

Compositions and methods for enhanced aquatic farming and aquarium fish husbandry

The subject invention provides compositions and methods for preserving food products. Specifically, the subject compositions and methods can be used to prolong the consumable life of food products, as well as to reduce and/or prevent spoilage and/or contamination by microbial agents. Preferably, the compositions comprise a blend of one or more glycolipids and one or more lipopeptides. Even more preferably, the compositions comprise sophorolipids and surfactin, lichenysin or another lipopeptide biosurfactant.

Organic food preservative compositions

The subject invention provides compositions and methods for simultaneously enhancing oil recovery, improving the quality of oil and gas through reduction in sulfur-containing compounds, and preventing and/or reducing corrosion of oil and gas production equipment. A multi-functional composition is provided comprising an antimicrobial biosurfactant component, a first ammonium salt, and ammonium hydroxide. In some embodiments, the efficiency of the composition is further enhanced by the addition of a chelating agent, a phenol (e.g., carbolic acid or phenolic acid), and/or an HS scavenger. In some embodiments, the composition is further enhanced for use in cold climates by the addition of an antifreeze mixture comprising one or more of a second ammonium salt, sodium chloride and glycerol.

Multifunctional composition for enhanced oil recovery, improved oil quality and prevention of corrosion

The subject invention provides yeast-based products, as well as their use to improve industrial production and performance by, for example, efficiently cleaning contaminating and/or fouling substances such as FOG, biofilm, paraffin, and/or asphaltenes from industrial equipment.

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Solon, OH, United States of America

Ken Alibek