University of Michigan

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Jon Oscherwitz

Gabriel Nunez

Tyler Nygaard

Yumi Nakamura

Cortland J Lohff

Materials and methods are provided for treatment and/or prevention of Staphylococcal diseases and disorders such as infection and dermal inflammation.

Treatment of staphylococcal disorders

The disclosure generally relates to the field of prevention and treatment ofinfections. In particular, the disclosure relates to immunogens comprisingantigens and methods for generating immune responses to immunogens, and to antibody products specific for theepitopes and methods for treatinginfection with the antibody products.

materials and methods

[object Object]

Plasmid vectors are provided which enable for the modification of double-stranded DNA which has blunt or one-base 3' overhanging termini, to include any desired four-base 5' overhang sequence, in the reading frame of choice. These vectors enable the cloning of blunt double-stranded DNA sequences or double-stranded DNA sequences having a one-base 3' overhang into a unique restriction site by blunt-end ligation or by one-base 3' overhang cohesive cloning such as T-cloning. The vectors may be amplified and subsequently excised, thereby producing modified fragments free of vector sequences.

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Ann Arbor, MI, United States of America

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