Anadys Pharmaceuticals, Inc.

Scriptgen Pharmaceuticals, Inc.

Kelvin T Lam

Yi Bin Xiang

Judith M Healy

David G Powers

Vincent Boyd

Andrea J Lesoon

Jana Bodorova

The present invention provides isolated nucleic acids encoding RNA polymerase alpha subunit from vectors comprising the nucleic acids, cells comprising the vectors, and methods for producing alpha subunit. The invention also provides in vitro and in vivo methods for high-throughput screening to identify inhibitors of RNA polymerase.

M. tuberculosis RNA polymerase alpha subunit

The invention relates to RNA polymerase algU sigma subunit protein, DNA encoding, and methods of detecting inhibitors of the RNA polymerase.

Nucleic acid encoding M. tuberculosis algu protein

Disclosed are pharmaceutical compositions and formulations comprising benzoquinoline derivatives having the formula (I) to (V), wherein formula (I) is:

Benzoquinoline derivatives useful as antibacterial agents

Disclosed are pharmaceutical compositions and formulations comprising the compound:

Aryldiamine derivatives useful as antibacterial agents

The subject invention, provides arylhydrazone compounds having the Formula 1: ##STR1## wherein A and B are independently aryl or heteroaryl and A and B independently are substituted with at least one group selected from alkyl, halogen, CN, COOR.sup.7, NR.sup.7 R.sup.8, CONR.sup.7 R.sup.8, NO.sub.2, SR.sup.7, SOR.sup.7, SO.sub.2 R.sup.7, NHCOR.sup.7, NHSO.sub.2 R.sup.7, OR.sup.7, hydroxyalkyl, and aminoalkyl. The compounds of this invention are useful for treating a wide variety of bacterial infections, including diseases of the skin, e.g., acne and skin ulcers, gastroenteritis, colitis, meningitis, keratinitis, conjunctivitis, diseases of the urinary and genital tracts, etc.

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Belmont, MA, United States of America

Kelvin T Lam