Pfizer Corporation

Kelvin Cooper

Kenneth Richardson

Michael J Fray

John Steele

Peter E Cross

Robert J Bass

Anthony Marfat

Wayne E Barth

James F Eggler

Allen Jacob Duplantier

Edward F Kleinman

Ralph P Robinson

Lawrence Alan Reiter

Michael J Parry

Tricyclic

A series of imidazo[4,5-c]pyridines which inhibit platelet activating factor (PAF) and also block leukotriene D4 receptors are useful in treating asthma, arthritis, psoriasis, gastrointestinal distress, myocardial infarction, stroke and shock.

Azabenzimidazoles in the treatment of asthma, arthritis and related

Antiinflammatory and analgesic oxindole prodrugs of the formula ##STR1## wherein R.sup.10, R.sup.11, R.sup.12 and R.sup.13 are hydrogen, alkyl or halogen and R is methyleneoxyalkanoyl, methyleneoxyalkenoyl or alkenoyl.

Prodrugs of antiinflammatory 3-acyl-2-oxindole-1-carboxamides

##STR1## A compound of formula (I), where Ar is optionally substituted phenyl or methylenedioxyphenyl or benzothienyl, R.sup.1 is alkyl, R.sup.2 is selected from hydroxy, alkoxy, alkylthio, alkyl and optionally substituted phenyl or amino, and 'Het' is a heterocyclic group. The compounds are platelet activating factor inhibitors.

Dihydropyrimidine antiallergy agents

##STR1## Platelet activating factor antagonists of formula (I), in which R.sup.2 is optionally substituted phenyl, R.sup.1 is H, alkyl or arylalkyl, Het is an optionally substituted N-containing heterocyclic group optionally fused to a phenyl or a further heterocyclic ring, and Z completes an optionally substituted carbocyclic or heterocyclic ring having a carbonyl group attached to the 5-position of the dihydropyridine ring. The compounds are useful for treating allergic and inflammatory conditions.

Dihydropyridine antiallergy agents

1,4-dihydropyridines useful as pharmaceuticals

Intermediates useful in the synthesis of dihydropyridine platelet activating factor antagonists of the formula ##STR1## where R is phenyl or substituted phenyl; R.sup.3 is lower alkyl; Y is 1,4-phenylene and X is 2-alkylimidazopyridyl.

Alkyl 2-benzylidene-4-(2-alkylimidazopyrid-1-yl) benzoylacetate esters

Platelet activating factor antagonists of formula (I): ##STR1## wherein R is phenyl or phenyl substituted by one or more substituents selected from nitro, halo, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, aryl(C.sub.1 -C.sub.4)alkoxy, fluoro(C.sub.1 -C.sub.4)alkoxy, C.sub.1 -C.sub.4 alkylthio, C.sub.1 -C.sub.4 alkylsulphonyl, hydroxy, trifluoromethyl and cyano, or is phenyl fused to a dioxole ring;

Platelet activating factor antagonists

Platelet activating factor antagonists of formula (I), (II) or (III): ##STR1## where A is optionally substituted benzene, pyridine, naphthalene, quinoline, thiophene, benzothiophene, pyrazole or isothiazole,

Diazepine antiallergy agents

Compounds of the formula ##STR1## where R.sup.1 is lower alkyl, R.sup.2 is chlorophenyl, Y is alkylene, X is heterocyclic and Z is a fused ring are useful as antiinflammatory and antiallergy agents.

Certain oxo-pyrrolo 1,4-dihydropyridines as antiallergy and

The invention provides compounds of the formula ##STR1## and pharmaceutically acceptable salts thereof, wherein R is phenyl substituted by halo;

1,4-dihydropyridine derivatives

Platelet activating factor antagonists of formula (I): ##STR1## wherein R is phenyl or phenyl substituted by one or more substituents selected from nitro, halo, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, aryl (C.sub.1 -C.sub.4) alkoxy, fluoro (C.sub.1 -C.sub.4) alkoxy, C.sub.1 -C.sub.4 alkylthio, C.sub.1 -C.sub.4 alkylsulphonyl, hydroxy, trifluoromethyl and cyano, or is phenyl fused to a dioxole ring;

4-Aryl-2,6-disubstituted-3,5-dicarbamyl-1,4-dihydropyridines and 4-Aryl-2,6-disubstituted-3-alkoxycarbonyl-5-carbamyl-1,4-dihydropyridines as antiallergy and antiinflammatory agents.

Dihydropyridine antiallergic and antiinflammatory agents

4-Aryl-3-alkoxycarbonyl-6-methyl-5-carbamyl-2-triazolylalkoxymethyl-1,4-dih yd ropyridines as anti-allergic and anti-inflammatory agents.

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Deal, United Kingdom

Kelvin Cooper