Kbio Holdings Limited

Kentucky Bioprocessing, Inc.

Kelsi Swope

Barry Bratcher

Steven D Hume

Joshua D Morton

Greg Pogue

Nick Partain

John W Shepherd

Hugh A Haydon

Leigh Burden

Carrie A Simpson

Josh Morton

Emmett Ernest Hiatt, Iii

Larry Zeitlin

Emmett Ernest Hiatt

Emmett Ernest Iii Hiatt

Disclosed herein are methods and exemplary compositions associated with antigen purification, exemplary aspects of which may include harvesting viral and antigenic substances from source organisms; and a purification platform comprising chemical separation and size-difference separation for the removal of contaminants, debris and impurities from the viral and protein (e.g. antigenic, including influenza hemagglutinin antigens) substances, as well as their concentration and collection.

Antigen purification

A new platform method to purify plant-based monoclonal antibodies is provided. Such a method includes an antibody purification platform that involves a standardized procedure for the production of a wide array of different antibodies within a simplified context. The versatility of the overall purification process accords a one-size-fits-all approach for myriad antibody products and includes plant tissue harvesting, extraction and clarification, filtrate generation, a succession of column chromatography procedures, and buffer exposure to provide the desired monoclonal antibodies in proper filtered and purified form for further incorporation and/or use within medicaments and other formulations. Thus, the purified monoclonal antibodies produced thereby such a method are also encompassed within this invention.

Method of purifying monoclonal antibodies

Growing community of inventors

Maceo, KY, United States of America

Kelsi Swope