Chinese Academy of Sciences

Kunshan Xinyunda Biotech Co., Ltd.

Kunshan Xinyunda Biotech Co., Ltd. Beijing Branch

Kelong Fan

Xiyun Yan

Fei Wang

Jing Feng

Meng Zhou

Minmin Liang

Xuehui Chen

Demin Duan

Di Lu

Dexi Zhang

Dongling Yang

A nanoscale drug carrier capable of crossing the blood-brain barrier. Said carrier can target brain lesions (brain tumors or other neurodegenerative diseases). The targeting drug carrier capable of crossing the blood-brain barrier comprises all-heavy-chain human ferritin or a functional fragments reconstituted structure or a mutant thereof. The manner for crossing the blood-brain barrier of the drug carrier is receptor-mediated transcytosis. The drug carrier provides an effective nanoscale drug carrier for the treatment of brain tumors or other neurodegenerative diseases.

Nanoscale drug carrier capable of passing through blood-brain barrier

The present disclosure relates to a tumor-targeted drug delivery system, comprising a tumor-targeted drug carrier and a tumor-treating drug, wherein the tumor-targeted drug carrier comprises full heavy-chain human ferritin. The present disclosure also relates to a method for preparing the tumor-targeted drug delivery system comprising: depolymerizing a polymerized full heavy-chain human ferritin; adding a tumor-treating drug to the depolymerized full heavy-chain human ferritin so as to bind the tumor-treating drug to the depolymerized full heavy-chain human ferritin; and re-polymerizing the depolymerized full heavy-chain human ferritin bound with the tumor-treating drug to form a nanoparticle.

Drug carrier for tumor-specific targeted drug delivery and use thereof

Growing community of inventors

Beijing, China

Kelong Fan