Massachusetts Institute of Technology

University of Pennsylvania

Boston University

Kelly R Stevens

Sangeeta N Bhatia

Christopher S Chen

Michael T Yang

Ritika Chaturvedi

Jan D Baranski

The present disclosure provides patterned biomaterials having organized cords and extracellular matrix embedded in a 3D scaffold. According, the present disclosure provides compositions and applications for patterned biomaterials. Pre-patterning of these biomaterials can lead to enhanced integration of these materials into host organisms, providing a strategy for enhancing the viability of engineered tissues by promoting vascularization.

Biomaterials for enhanced implant-host integration

Engineered human tissue seed constructs are provided that are suitable for implantation in subjects. Methods of making and using the engineered tissue seed constructs are provided.

In situ expansion of engineered devices for regeneration

Situ expansion of engineered devices for regeneration

The present disclosure provides patterned biomaterials having organized cords and extracellular matrix embedded in a 3D scaffold. According, the present disclosure is provides compositions and applications for patterned biomaterials. Pre-patterning of these biomaterials can lead to enhanced integration of these materials into host organisms, providing a strategy for enhancing the viability of engineered tissues by promoting vascularization.

The invention features an 'inverse patterning' or 'Intaglio-Void/Embed-Relief Topographic (In VERT) molding' manufacturing process for generating high-resolution three-dimensional (3D) multi-cellular microstructures in distinct cellular compartments of a single hydrogel. The platform has general utility in the development of engineered tissues for human therapies, drug testing, and disease models. Additionally, the platform can serve as a model system for studying 3D cell-cell interactions in fields as diverse as stem cell biology to the development of cancer therapeutics.

Growing community of inventors

Seattle, WA, United States of America

Kelly R Stevens