Pfizer Corporation

Bend Research, Inc.

Burroughs Wellcome Co.

Kelly L Smith

Scott Max Herbig

Avinash G Thombre

Richard W Korsmeyer

Paul Van Eikeren

Jeelin Lo

John R Cardinal

James W Brooke

Richard W Baker

Dwayne Thomas Friesen

Walter Christian Babcock

William John Curatolo

Leah Elizabeth Appel

Edward L Cussler

Ronald Arthur Beyerinck

Bruce M Johnson

James Blair West

Carl C Wamser

Mark B Chidlaw

Harold K Lonsdale

Dwayne T Friensen

Scott H Herbig

Matthew F Holmes

A controlled release dosage form has a coated core with the core comprising a drug-containing composition and a water-swellable composition, each occupying separate regions within the core. The drug-containing composition comprises a low-solubility drug and a drug-entraining agent. The coating around the core is water-permeable, water-insoluble and has at least one delivery port therethrough. A variety of formulations having specific drug release profiles are disclosed.

Hydrogel-driven drug dosage form

A durable and sprayable controlled release bead of active ingredient in the pores of a polymeric micro-porous bead having an anisotropic pore structure of large pores in the interior and small pores at the surface, the gradation of pore sizes between the interior and the surface being continuous.

Asymmetric microporous beads for controlled release

Osmotic devices having vapor-permeable coatings

There is disclosed a pesticidal composition comprising a pH-sensitive non-lignin-based polymer encapsulating both the active agent and a lignin-based UV screening agent.

Labile insecticide compositions

A device for controlled release of an active substance through one or more asymmetric membranes by diffusion and/or osmotic pumping.

Asymmetric membranes in delivery devices

Use of asymmetric membranes in delivery devices

An osmotic bursting device for dispensing a beneficial agent to an aqueous environment. The device comprises a beneficial agent and osmagent surrounded at least in part by a semipermeable membrane. Alternatively the beneficial agent may also function as the osmagent. The semipermeable membrane is permeable to water and substantially impermeable to the beneficial agent and osmagent. A trigger means is attached to the semipermeable membrane (e.g., joins two capsule halves). The trigger means is activated by a pH of from 3 to 9 and triggers the eventual, but sudden, delivery of the beneficial agent. These devices enable the pH-triggered release of the beneficial agent core as a bolus by osmotic bursting.

PH-triggered osmotic bursting delivery devices

Supported liquid membrane delivery devices that release a beneficial agent to an aqueous environment following exposure to an environmental trigger. A microporous hydrophobic support membrane at least partially surrounds a beneficial agent- containing hydrophilic formulation. A hydrophobic liquid is held within the microporous support membrane by capillarity and the hydrophobic liquid is substantially permeable to the aqueous environment and the beneficial agent-containing hydrophilic formulation. The entrained hydrophobic liquid becomes substantially permeable to the aqueous environment upon exposure to an environmental trigger such as an enzyme, and the beneficial agent is subsequently released.

Supported liquid membrane delivery devices

Interfacially-polymerized ultrathin films containing physicochemically functional groups are disclosed, both with and without supports. Various applications are disclsoed, including membrane electrodes, selective membranes and sorbents, biocompatible materials, targeted drug delivery, and narrow band optical absorbers.

Physicochemically functional ultrathin films by interfacial

Prills of pharmaceutically acceptable material are coated first with a water-permeable polymeric matrix containing a water-soluble pharmaceutically beneficial agent and then overcoated with a water-permeable film containing dispersed therein a water-soluble, particulate pore-forming material.

Delivery system

Growing community of inventors

Bend, OR, United States of America

Kelly L Smith