The University of Arizona

University of Hawai'i

Biosynthetic Technologies, LLC

Kelly Forest

Jakob Bredsguard

Jeremy Forest

Travis Thompson

Victor J Hruby

Robert A Nichols

Peptide analogues of β-amyloid and methods of using said analogues for neuroprotection are described herein. The β-amyloid peptide analogues have a sequence that is at least 50% identical to an N-terminal β-amyloid core fragment. A pharmaceutical composition of the β-amyloid peptide analogues in a pharmaceutically acceptable carrier can be administered to a subject for neuromodulation. The β-amyloid peptide analogues, while lacking neurotoxicity, effectively provides for protective activity against β-amyloid toxicity.

Neuroprotective beta amyloid core peptides and peptidomimetic derivatives

Provided herein are estolide base oils and oligomeric compounds prepared from processes that include cross metathesis. Exemplary processes include the preparation of terminally-unsaturated fatty acids by cross metathesis, and the subsequent oligomerization of terminally-unsaturated fatty acids to provide estolide compounds, such as the process set forth below: 

Processes for preparing estolide base oils and oligomeric compounds that include cross metathesis

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Honolulu, HI, United States of America

Kelly Forest