University of Florida Research Foundation, Incorporated

Kelly E Gridley

James W Simpkins

Pattie S Green

A method is provided for preserving tissues during removal, storage and implantation into a subject by enhancing cell viability in a population of graft cells during the transplantation procedure. The method includes selecting an effective dose of a polycylic phenolic compound in a physiologically acceptable formulation and exposing at least the population of graft cells to the formulation containing the compound within a time that is effectively proximate to the transplantation procedure so as to confer cytoprotection on the population of graft cells.

Preservation of tissue during removal storage and implantation

The present invention concerns methods and compositions for enhancing the cytoprotective effects of polycyclic phenolic compounds through the synergistic interaction with anti-oxidants.

Methods and compositions to enhance the cytoprotective effects of

A method is provided for preserving tissues during removal storage and implantation by enhancing cell viability in a population of graft cells during the transplantation procedure The method includes selecting an effective dose of a cyclopentanophenanthrene compound having a terminal phenol A ring in a physiologically acceptable formulation and exposing at least one of: a donor at an effective dose prior to removal of the cells; the population of cells in an ex vivo storage medium;, and a recipient tissue at an effective time prior to association with the donor graft cells; so as to confer cytoprotection on the population of graft cells.

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Gainesville, FL, United States of America

Kelly E Gridley