Aprecia Pharmaceuticals LLC

Aprecia Pharmaceuticals Company

Kelly E Caputo

Thomas George West

Jules S Jacob

Micael Guillot

Kenneth J Sultzbaugh

Mahendra R Patel

Jaedeok Yoo

Thomas J Bradbury

Aleece M Phillips

Matthew F Boldt

Timothy S Tracy

Henry Cabral

William R Gross

Lauren E Beach-Herrera

Munhee Lee

A method and system of forming a pharmaceutical dosage form within a portion of a blister packaging. The method includes the steps of providing a blister packaging for the dosage form with depressions. A predetermined amount of a drug-containing powder material comprising drug-containing particles is deposited into a substantially uniform powder layer within the depressions. A binding liquid is then deposited in a pattern on the powder layer within the depressions, to bind the particles of the powder layer and form an incremental wetted layer. Excess solvent in the binding material can be removed to form an incremental bound layer. These steps are repeated in sequence at least one or more times to form the pharmaceutical dosage form within the blister packaging.

Method and system for forming a dosage form within a packaging

A high dose orodispersible dosage form of oxcarbazepine is provided. Drug-containing particles of oxcarbazepine are included within a porous bound matrix. The dosage form disperses in saliva or water in less than 15 sec and it has sufficient hardness to withstand handling and storage. It can be used to treat diseases or disorders that are therapeutically responsive to oxcarbazepine or a derivative thereof.

Rapidly dispersible dosage form of oxcarbazepine

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Langhorne, PA, United States of America

Kelly E Caputo