Irm LLC

Novartis Ag

Kelli L Kuhen

Tao Jiang

Yun He

Baogen Wu

David Archer Ellis

Tao Wu

Arnab Kumar Chatterjee

David C Tully

Advait Suresh Nagle

Badry Bursulaya

Truc Ngoc Nguyen

Xiaohui He

Kunyong Yang

Tom Yao-Hsiang Wu

Jeremy S Caldwell

Beth Anaclerio

The invention provides a class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent malaria.

Compounds and compositions for the treatment of parasitic disease

Compounds and compositions for the treatment of parasitic diseases

Compounds and compositions useful for the treatment of parasitic diseases

This invention provides novel methods for identifying agents that inhibit HIV infection. The anti-HIV agents are identified by screening test compounds for ability to modulate a biological activity of isopeptidase T (IsoT), e.g., its isopeptidase activity or its binding to another molecule such as viral protein R (Vpr). Such IsoT modulators can be further examined for their activity in inhibiting an activity indicative of HIV infection or HIV replication. These novel anti-HIV agents are useful in the prevention or treatment of HIV infection and conditions associated with or caused by HIV infection.

Methods and compositions for inhibiting HIV infection

The present invention relates to inhibition of viruses, e.g., HIV using pyrrolidones and compounds related to pyrrolidones. The invention further relates to methods for identifying and using agents, including small molecule chemical compositions that inhibit HIV in a cell; as well as to methods of prophylaxis, and therapy related to HIV infection and related disease states such as AIDS.

Pyrrolidones with anti-HIV activity

The present invention relates to inhibition of viruses, e.g., HIV using oxindoles and compounds related to oxindoles. The invention further relates to methods for identifying and using agents, including small molecule chemical compositions that inhibit HIV in a cell; as well as to methods of prophylaxis, and therapy related to HIV infection and related disease states such as AIDS.

Oxindoles with anti-HIV activity

The present invention relates to inhibition of viruses, e.g., HIV using quinolones and compounds related to quinolones. The invention further relates to methods for identifying and using agents, including small molecule chemical compositions that inhibit HIV in a cell; as well as to methods of prophylaxis, and therapy related to HIV infection and related disease states such as AIDS.

Quinolones with anti-HIV activity

Growing community of inventors

Solana Beach, CA, United States of America

Kelli L Kuhen