Colin Corporation

Colin Medical Technology Corporation

Keizoh Kawaguchi

Akihiro Yokozeki

Hidekatsu Inukai

Kiyoyuki Narimatsu

Tomohiro Nunome

Chikao Harada

Atsushi Sato

A blood pressure monitor apparatus for monitoring a blood pressure of a living subject, wherein the blood pressure is judged to be abnormal when a first change value as a change of each of a plurality of blood pressure values iteratively obtained from the subject, from a standard blood pressure obtained from the subject, does not fall in a first reference range (TH), wherein the improvement comprises: the first reference range being determined based on the standard blood pressure of the subject, according to a relationship between first reference range and standard blood pressure wherein a plurality of different first reference ranges correspond to a plurality of different standard blood pressures, respectively.

Blood pressure monitor apparatus

A dialyzing apparatus includes a dialyzer which removes water from blood of a patient at a water-remove rate during a dialysis operation, a blood-pressure-change-related-information obtaining device which obtains a plurality of sorts of blood-pressure-change-related information each of which is related to a change of a blood pressure of the patient during the dialysis operation, and a water-remove-rate control device which controls the water-remove rate of the dialyzer, based on the plurality of sorts of blood-pressure-change-related information, according to a predetermined control manner.

Dialyzing apparatus

A dialyzing apparatus includes a dialyzer which removes water from blood of a patient at a pre-set water-remove rate, an autonomic-nerve-activity-related-information obtaining device which obtains autonomic-nerve-activity-related information that is related to an activity of an autonomic nerve of the patient, and a water-remove-rate display device which displays a target water-remove rate based on the autonomic-nerve-activity-related information obtained by the autonomic-nerve-activity related-information obtaining device.

A heart-sound detecting apparatus, including: a heart-sound microphone which detects a plurality of heart sounds produced by a heart of a living subject and outputs a heart-sound signal representative of the detected heart sounds; a smoothing device for smoothing, by differentiation, a waveform of the heart-sound signal output from the heart-sound microphone; a squaring device for squaring an amplitude of the smoothed waveform with respect to a base line of the heart-sound signal; and a start-point determining device for determining a start point of a first heart sound I as one of the detected heart sounds, based on that the squared amplitude is greater than a prescribed threshold value.

Heart-sound detecting apparatus and pulse-wave-propagation-velocity-relating-information obtaining system using the heart-sound detecting apparatus

An apparatus for evaluating a degree of arteriosclerosis of a living subject, including: a pulse-wave detecting device adapted to be worn on a first portion of the living subject; a pressing device adapted to be worn on a second portion of the subject located on a distal side of the first portion, for pressing the second portion so as to restrict a flow of blood at the second portion; and an arteriosclerosis-related information obtaining device which obtains arteriosclerosis-related information used for evaluating said degree of arteriosclerosis of the subject, based on a peak point of an incident-wave component, and a peak point of a reflected-wave component, of a pulse of a pulse wave that is detected by the pulse-wave detecting device in a state in which the flow of blood is restricted by the pressing device.

Arteriosclerosis-degree evaluating apparatus

A dialyzing apparatus including a dialyzer which removes water from blood of a patient at a water-remove rate, an arteriosclerosis-related-information obtaining device which obtains arteriosclerosis-related information that is related to a degree of arteriosclerosis of the patient, and a water-remove-rate display device which displays a target value of the water-remove rate based on the arteriosclerosis-related information obtained by the arteriosclerosis-related-information obtaining device.

The gate means extracts the partial impedance pulse wave SM from the thorax impedance pulse wave SM detected by the thorax impedance pulse wave detector . This is done over an intake period defined as a period starting from a first time T after the time when the R wave of the induced electro-cardiac wave is detected to the time when a rising edge of the photoelectric pulse wave SM is detected. Then, the heartbeat synchronous information determining means selects a rising edge of the partial impedance pulse wave SM that periodically appears as heartbeat synchronous information I . Thus, it is possible to accurately determine the heartbeat synchronous information I . Additionally, since the photoelectric pulse wave SM that is detected by the photoelectric pulse wave sensor is largely free of noise it is possible to accurately determine the end of the period for reading the thorax impedance pulse wave SM .

Heartbeat synchronous information acquiring apparatus

A blood pressure monitor apparatus for monitoring a blood pressure of a living subject, comprising: pulse-wave-propagation-velocity-relating information obtaining means for successively obtaining pulse-wave-propagation-velocity-relating information which relates to a pulse-wave propagation velocity at which a pulse wave propagates in an artery of the subject; pulse-period-relating information obtaining means for successively obtaining pulse-period-relating information which relates to a pulse period of the subject; peripheral-blood-volume-relating information obtaining means for successively obtaining peripheral-blood-volume-relating information which relates to a volume of blood which flows in a peripheral body portion of the subject; and abnormality judging means for judging that the blood pressure of the subject is abnormal when at least one of the pulse-wave-propagation-velocity-relating information, pulse-period-relating information, and peripheral-blood-volume-relating information does not fall within a corresponding one of a first, a second and a third reference range.

An apparatus for estimating a blood pressure of a living subject, including a measuring device which iteratively measures a blood pressure of the subject, a first device for obtaining first information relating to velocity of propagation of pulse wave, a second device for obtaining at least one of second information relating to heart rate and third information relating to area defined by volume pulse wave, a memory which stores groups of information each group of which includes the blood pressure, the first information, and at least one of the second information and the third information, a determining device for determining an expression representing a relationship between (A) blood pressure, and (B ) first information and (B ) at least one of (B ) second information and (B ) third information, and having a first coefficient for the first information, at least one second coefficient for at least one of the second and third information, and a constant, the determining device determining the coefficients and constant of the expression by applying a multiple regression analysis to more than a predetermined number of groups of information last stored in the memory, the predetermined number being equal to a total number of the coefficients and the constant, and an estimating device for successively estimating, according to the expression, a blood pressure of the subject based on each first information and at least one of each second information and each third information.

Blood pressure estimating apparatus

A blood pressure monitor apparatus for monitoring a blood pressure of a living subject, comprising: blood pressure-relating information obtaining means for successively obtaining blood pressure-relating information which decreases or increases with a decrease or an increase of the blood pressure of the subject, or blood pressure-relating information which increases or decreases with a decrease or an increase of the blood pressure of the subject; decrease or increase determining means for determining a decrease or an increase of the blood pressure-relating information successively obtained by the obtaining means; and abnormality judging means for judging that the blood pressure of the subject is abnormal when the decrease or increase of the blood pressure-relating information is greater than a predetermined reference value (&ggr; , &ggr; ), or abnormality judging means for judging that the blood pressure of the subject is abnormal when the blood pressure-relating information is greater than a predetermined reference value (TH ) or smaller than a predetermined reference value (TH ).

A heart-sound detecting apparatus, including a heart-sound microphone which detects at least one heart sound produced by the heart of a living subject and outputs a heart-sound signal representing the detected heart sound, a time-frequency analyzing device for analyzing, with respect to time and frequency, at least a portion of the heart-sound signal that includes a first heart sound I, and an aortic-valve-opening-timing determining device for determining a timing when the aortic valve of the heart opens, based on a time when a magnitude of the analyzed signal at a frequency higher than a frequency range of a main component present in an initial portion of the first heart-sound I is greater than a prescribed threshold value.

HEART-SOUND DETECTING APPARATUS, SYSTEM FOR MEASURING PRE-EJECTION PERIOD BY USING HEART-SOUND DETECTING APPARATUS, AND SYSTEM FOR OBTAINING PULSE-WAVE-PROPAGATION-VELOCITY-RELATING INFORMATION BY USING HEART-SOUND DETECTING APPARATUS

A device for monitoring the blood pressure of a living subject, including a pulse-wave-propagation-velocity-relating information obtaining device for successively obtaining pulse-wave-propagation-velocity-relating information which relates to a pulse-wave propagation velocity at which a pulse wave propagates in an artery of the subject, a pulse-period-relating information obtaining device for successively obtaining pulse-period-relating information which relates to a pulse period of the subject, a peripheral-blood-volume-relating information obtaining device for successively obtaining peripheral-blood-volume-relating information which relates to a volume of blood which flows in a peripheral body portion of the subject, and an abnormality judging device for judging that the blood pressure of the subject is abnormal when at least one of the pulse-wave-propagation-velocity-relating information, pulse-period-relating information, and peripheral-blood-volume-relating information does not fall within a corresponding one of a first, a second and a third reference range.

An apparatus for estimating an intraarterial blood pressure of a living subject, based on information non-invasively obtained from a circulatory organ of the subject, including: a first device for obtaining first information which relates to velocity of propagation of a pulse wave; a second device for obtaining at least one of second information which relates to heart rate and third information which relates to an area defined by a volume pulse wave; a third device for estimating, according to a predetermined relationship to between (A) blood pressure, and (B1) first information and (B2) at least one of (B21) second information and (B22) third information, the blood pressure, based on the first information and the at least one of the second information and the third information, the predetermined relationship being defined by a numerical expression including a plurality of predetermined coefficients; and a fourth device for selecting, from a plurality of groups of predetermined coefficients which correspond to a plurality of blood-pressure ranges, respectively, one group of predetermined coefficients which corresponds to a blood pressure, so that the third device estimates the blood pressure according to the numerical expression including the selected group of predetermined coefficients.

Blood pressure estimating apparatus and method

An apparatus for successively estimating an intraarterial blood pressure of a living subject, based on information non-invasively obtained from a circulatory organ of the subject, including: a first device for non-invasively obtaining, from the circulatory organ of the subject, first information which relates to velocity of propagation of a pulse wave which propagates through an artery of the subject; a second device for non-invasively obtaining, from the circulatory organ of the subject, at least one of second information which relates to heart rate of the subject and third information which relates to an area defined by a volume pulse wave from a peripheral portion of the subject; and a third device for estimating, according to a predetermined relationship between (A) blood pressure, and (B1) first information and (B2) at least one of (B21) second information and (B22) third information, the intraarterial blood pressure of the subject, based on the first information obtained by the first device and the at least one of the second information and the third information obtained by the second device.

An apparatus for estimating an intraarterial blood pressure of a living subject, based on information of the subject, including: a first device for obtaining first information which relates to velocity of propagation of a pulse wave; a second device for obtaining at least one of second information which relates to heart rate and third information which relates to an area defined by a volume pulse wave; a third device for estimating, according to a predetermined relationship between (A) blood pressure, and (B1) first information and (B2) at least one of (B21) second information and (B22) third information, the blood pressure of the subject, based on the first information and the at least one of the second and the third information, the relationship being defined by a numerical expression including a plurality of coefficients; a fourth device for determining an activity of an autonomic nerve system, based on at least one of fourth information which relates to fluctuations of the blood pressure and fifth information which relates to fluctuations of the heart rate; and a fifth device for changing, based on the activity of the autonomic nerve system, at least one of the coefficients of the expression, so that the expression including the changed coefficient amplifies a change of an estimated blood pressure from a prior estimated blood pressure.

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Komaki, Japan

Keizoh Kawaguchi