Nissan Chemical Industries Limited

The Green Cross Corporation

Keizo Tanikawa

Ken-ichi Shikada

Ryozo Sakoda

Nobutomo Tsuruzoe

Takashi Matsumoto

Masayuki Sato

Kazufumi Yanagihara

Kazuhiko Ohrai

Toru Yamashita

Yoshimasa Kamikawaji

Akira Saito

Yukihiro Shigeta

Keisuke Odoi

Yukinori Masuda

Tsutomu Higashiyama

Toru Tsukagoshi

Motoo Mutsukado

Mitsuaki Hirotsuka

Katsuaki Miyaji

Hiroo Matsumoto

Hitomi Suzuki

Sakuya Tanaka

Hitoshi Nakabeppu

Koichi Maeda

Takehisa Iwama

Norifumi Nakamura

Teruaki Imada

Norimasa Shudo

Ruriko Ikegawa

Yoichiro Fujita

Yasunori Asada

Masumi Nakamura

Nobuhiro Suzuki

Ryozo Saloda

Kenichi Shikada

Akiko Yamamoto

This invention relates to a 4-oxybenzopyran derivative of formula (I) wherein, R and R represent each independently a hydrogen atom, a C alkyl group or a phenyl group; R represents a hydroxyl group or C alkylcarbonyloxy group; R represents a hydrogen atom, a C cycloalkyl group, a C alkyl group, a C alkylcarbonyl group, a C alkylaminocarbonyl group, a di-C alkylaminocarbonyl group, an aryl group or a heteroaryl group; R represents a hydrogen atom or a C alkyl group; X is absent or represents C&boxH;O or SO ; R represents a hydrogen atom, a C alkyl group or a C cycloalkyl group; R represents a hydrogen atom, a halogen atom, a nitro group or a cyano group; or a pharmaceutically acceptable salt thereof. And this invention also relates to a drug for treating arrhytmia having the prolongation effect on the functional refractory period comprising said compound or a pharmaceutically acceptable salt thereof as an active ingredient.

4-oxybenzopyran derivative

Benzopyran derivative

This invention relates to a 4-oxybenzopyran derivative of formula (I) wherein, R and R represent each independently a hydrogen atom, a C alkyl group or a phenyl group; R represents a hydroxyl group or a C alkylcarbonyloxy group; R represents a hydrogen atom, a C cycloalkyl group, a C alkyl group, a C alkylcarbonyl group, a C alkylaminocarbonyl group, a di-C alkylaminocarbonyl group, an aryl group or a heteroaryl group; n represents an integer of 0-4; X represents &mdash;C(&boxH;O)NR &mdash;, &mdash;NR &mdash;, &mdash;NHC(&boxH;O)NH&mdash; or &mdash;S(O) NH&mdash;; R5 represents a hydrogen atom or (a), (b), (c), (d), (e), (f), (g), (h), (i), (j), (k), or (l); R represents a hydrogen atom, a halogen atom, a nitro group or a cyano group; or a pharmaceutically acceptable salt thereof. And this invention also relates to an antiarrhythmic agent having the prolongation effect of the functional refractory period comprising said compound or a pharmaceutically acceptable salt thereof as an active ingredient.

Indane derivatives

Benzimidazole compound

The present invention relates to chroman derivatives of the formula (I): ##STR1## [wherin R.sup.1 represents a hydrogen atom, a halogen atom, a C.sub.1-6 alkyl group, a C.sub.1-6 alkoxy group, a C.sub.3-6 alkoxymethyl group, etc., R.sup.3 and R.sup.4 each independently represent a hydrogen atom, a C.sub.1-6 alkyl group, etc., R.sup.5 represents a hydroxyl group or a C.sub.1-6 alkylcarbonyloxyl group or forms a bond together with R.sup.5, R.sup.6 represents a hydrogen atom or forms a bond together with R.sup.5, R.sup.7 and R.sup.8 each independently represent a hydrogen atom, a C.sub.1-6 alkyl group, a C.sub.3-6 cycloalkyl group, a phenyl group, etc. n is 0 or an integer of 1, 2, 3 or 4, W represents a phenyl group, etc., X represents C.dbd.O, CH.sub.2, SO.sub.2, etc., Y represents NR.sup.17 (in which R.sup.17 represents a hydrogen atom, a C.sub.1-4 alkyl group, a phenyl group, etc.), etc., Z does not exist or represents CH.sub.2 or NR.sup.18 (R.sup.18 represents a hydrogen atom, a C.sub.1-4 alkyl group, or a phenyl group, etc.)] or their salts.

Chroman derivatives

Pyrazolones derivatives

Organic bismuth derivatives for X-ray imaging

A 3(2H)-pyridazinone derivative of the formula (I) its salt, a process for its production and a pharmaceutical composition containing it. ##STR1## wherein each of R.sup.1, R.sup.2 and R.sup.3 which are independent of one another, is a hydrogen atom or a C.sub.1-4 alkyl group, X is a chlorine atom or a bromine atom, Y.sup.1 is a hydrogen atom, a halogen atom, a nitro group, an amino group or a C.sub.1-4 alkoxy group, Y.sup.2 is a hydrogen atom, a halogen atom, a hydroxyl group, a C.sub.1-4 alkyl group or a C.sub.1-4 alkoxy group, A is a C.sub.1-5 alkylene chain which may be substituted by a hydroxyl group, B is a carbonyl group or a methylene chain which may be substituted by a C.sub.1-4 alkyl group, and each of R.sup.4 and R.sup.5 which are independent of each other, is a C.sub.1-4 alkyl group, or R.sup.4 is a hydrogen atom and R.sup.5 is --Z--Ar (wherein Z is a C.sub.1-5 alkylene chain, and Ar is an aromatic 6-membered ring which may contain a nitrogen atom), or R.sup.4 and R.sup.5 together form a C.sub.2-6 cyclic alkylene group, or R.sup.4 and R.sup.5 form together with the adjacent nitrogen atom a 4-substituted piperazine ring of the formula: ##STR2## wherein R.sup.6 is a C.sub.1-4 alkyl group.

Pyridazinone derivatives with pharmaceutical activity

Pyridazinone derivatives represented by the formula (I) and antiplatelet agents containing them: ##STR1## �wherein R is a hydrogen atom or a C.sub.1 -C.sub.4 alkyl group, X is a hydrogen atom, a chlorine atom or a bromine atom, Ar is a pyridyl group or a phenyl group substituted with OR.sup.1 (wherein R.sup.1 is a hydrogen atom or a C.sub.1 -C.sub.4 alkyl group) and A {wherein A is a hydrogen atom, a halogen atom, a C.sub.1 -C.sub.4 alkyl group or OR.sup.2 (wherein R.sup.2 is a hydrogen atom or a C.sub.1 -C.sub.4 alkyl group)}, Y is C.sub.1 -C.sub.8 alkylene wherein one carbon atom on the straight chain is substituted with one OR.sup.1 group (wherein R.sup.1 is the same as defined above), and Z.sup.1 and Z.sup.2 are independently a hydrogen atom, a halogen atom, a C.sub.1 -C.sub.4 alkyl group or a OR.sup.1 group (wherein R.sup.1 is the same as defined above)!. These compounds have strong antiplatelet effects, are excellently safe, and can be used as active ingredients of prophylactic and therapeutic drugs for various thrombotic diseases.

Pyridazinone derivatives

Pyrazole compounds of formula �1! and their tautomers and salts: ##STR1## (wherein R.sup.1 is an alkyl group, etc.; R.sup.2 is a carboxyl group, etc.; R.sup.3 is a halogen atom, an alkyl group, a phenyl group, etc.; R.sup.4, R.sup.5 and R.sup.6 each are a hydrogen atom, a halogen atom, etc.; R.sup.7 is a carboxyl group, a 5-tetrazolyl group, etc.; X is a nitrogen atom, etc.; Y and Z each are CH, a nitrogen atom, etc.; A and E each are a methylene group, etc.; D is a phenyl group, etc.; G is a covalent bond, etc.). The compounds of the invention have an antagonistic effect against angiotensin II and are useful for prevention and remedy of hypertension, congestive cardiac insufficiency, chronic renal insufficiency, aldosteronism, hyper-intraocular pressure, etc.

Pyrazole derivatives

Agent for prophylaxis and treatment of thromboxane A.sub.2 -mediated

Growing community of inventors

Funabashi, Japan

Keizo Tanikawa