Eisai Company, Limited

Keizo Takayanagi

Yasuhide Tanaka

Masahiko Tsujii

Takeo Kanai

Eiichi Morita

Nobuo Niikawa

Yukio Morita

Shigeharu Nochi

Isao Yamatsu

Shigeto Negi

Seiichiro Nomoto

Shizumasa Kijima

Isao Sugiyama

Fujio Nakamura

Kimio Hamamura

Hiroshi Yamauchi

Yuuki Komatu

Atsushi Koiwa

Tasuke Kawabata

Shinichi Endoh

Hirosaburo Ejiri

Sulfoxide compounds and acetone complexes, and a process for producing the same

A novel 4-cyanopiperidine derivative, which is represented by the following general formula (I): ##STR1## wherein X means a halogen atom, or an acid addition salt thereof, is prepared by reacting N-(2-hydroxyethyl)-4-carbamoylpiperidine or an acid addition salt thereof with a dehydrating and halogenating agent; or by reacting 4-cyanopiperidine or a salt thereof with a compound represented by the following general formula (IV):

4-cyanopiperidine derivatives

Improved process for the preparation of 7-(2-amino-2-phenyl-acetamido)cephem derivatives of the general formula (I): ##STR1## wherein R.sub.1 is a hydrogwn atom or hydroxyl group, n stands for 0, 1 or 2, and A denotes a nitrogen-containing heterocyclic group or a direct bond coupling directly the sulfur atom and the --(CH.sub.2).sub.n COOH group together, as well as pharmaceutically acceptable salts thereof. The process is not only simple and easy to carry out, but also provides as crystalline precipitate the intended products with a high yield. The 7-(2-amino-2-phenyl-acetamido)cephem derivatives are useful as intermediates for syntheses of antibacterial agents.

Process for the preparation of 7-(2-amino-2-phenylacetamido) cephem

2-METHYL-3-PRENYL-4,5,6-TRIMETHOXYPHENOL OF THE FORMULA: ##STR1## wherein R represents a group of the formula: ##STR2## WHEREIN N IS AN INTEGER OF 0 TO 9 AND A and B represent hydrogen atom or A--B may form a bond, Is prepared by reacting 6-methyl-2,3,4-trimethoxyphenol with a prenol or isoprenol substituted by the group R as defined above in the presence of a complex catalyst comprising Lewis acid and a silica-alumina compound.

Process for preparing 2-methyl-3-prenyl-4,5,6-trimethoxyphenol

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Gumma, Japan

Keizo Takayanagi