Japan Atomic Energy Research Institute

Other

Takeda Chemical Industries, Inc.

Takeda Chemical Indus., Ltd.

Keizo Shida

Masaru Yoshida

Isao Kaetsu

Masaharu Asano

Hidetoshi Yamanaka

Katsuyuki Nakai

Akira Shiraishi

Hisako Yuasa

A slow-release composite having pyroglutamyl-histidyl-triptophyl-seryl- tyrosyl-D-leucyl-leucyl-arginyl-proline ethylamide or a salt thereof encapsulated in a polymer matrix and a process the same are herein disclosed.

Slow-release composite and process for producing the same

A slow-release composite having pyroglutamyl-histidyl-triptophyl-seryl-tyrosyl-D-leucyl-leucyl-arginyl-pro line ethylamide or a salt thereof encapsulated in a polymer matrix and a process the same are herein disclosed.

An Estracyt compound having a carcinostatic bound thereto is obtained by reacting an Estracyt compound with a carcinostatic having one or more radicals selected from among COOH, Cl, NH.sub.2 and OH, either directly or after reaction with an amine to replace one or both Cl groups in the nitrogen mustard portion in the Estracyt compound with a NH.sub.2 group, in the presence or absence of a catalyst. The resulting compound is more effective in cancer control than the Estracyt compound associated substance.

Process for preparing Estracyt compounds having a carcinostatic bound

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Gunma, Japan

Keizo Shida