Tanabe Seiyaku Company, Limited

Keizo Kinashi

Jyoji Kato

Naoto Yoneda

Kimiaki Hayashi

Takashi Ochiai

Novel 2-oxo-imidazolidine derivative of the formula: ##STR1## wherein R.sup.1 is lower alkyl or phenyl-lower alkyl, R.sup.2 is lower alkyl, R.sup.3 is alkyl of one to 12 carbon atoms or phenyl-lower alkyl and R.sup.4 is hydrogen or lower alkyl, and a pharmaceutically acceptable salts thereof are disclsoed. Said compounds (I) and salts thereof are useful as hypotensive agents.

Antihypertensive 2-oxo-imidazolidine derivatives

A 2-oxoimidazolidine derivative of the formula: ##STR1## wherein R.sup.1 is lower alkyl or phenyl-lower alkyl and R.sup.2 is lower alkyl or phenyl, and a process for preparation thereof are disclosed. Said 2-oxoimidazolidine derivative (I) or a pharmaceutically acceptable salt thereof is useful as a hypotensive agent.

2-Oxoimidazolidine derivatives

A tetrahydroisoquinoline compound of the formula: ##STR1## wherein R.sup.1 is alkyl of one to six carbon atoms, cycloalkyl of three to six carbon atoms, allyl or propargyl, R.sup.2 is hydrogen or alkyl of one to six carbon atoms, and R.sup.3 is hydrogen, alkyl of one to six carbon atoms or benzyl. Methods for preparing the compound (I) are disclosed. The compound (I) and a pharmaceutically acceptable salt thereof are useful as a diagnostic or therapeutic agent for angiotensin-related hypertension.

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Yao, Japan

Keizo Kinashi