Otsuka Pharmaceutical Company, Limited

Keizo Kan

Michiaki Tominaga

Hidenori Ogawa

Yoichi Yabuuchi

Kazumi Kondo

Hiroshi Yamashita

Tomoichi Shinohara

Muneaki Kurimura

Yoshihisa Tanada

Takashi Nakagawa

Makoto Sakamoto

Koichi Yasumura

Shigekazu Fujita

Takayuki Matsuzaki

Takumi Sumida

Yutaka Kojima

Keisuke Miyajima

Hideki Takasu

Takeshi Kodama

Satoshi Yamada

Hirotaka Tanaka

Yasuhiro Menjo

Tae Fukushima

Hokuto Yamabe

Masaaki Motoyama

Satoshi Matsuda

Naoto Ohi

Kazuhiro Ohdachi

Hideto Fujiwara

Hironori Matsuyama

Masatoshi Takuwa

Taiki Hanari

Tatsuya Urushima

Takashi Suzuki

Nobuaki Ito

Kuninori Tai

Minoru Uchida

Kenji Yoshida

Michinori Tanaka

Seiji Akamatsu

Fujio Tabusa

Noriaki Takemura

Yasuo Yanagihara

Toyoki Mori

Kazuhisa Sugiyama

Seiji Morita

Kazuo Sekiguchi

Mitsuhiro Okuno

Kunihiko Kiyono

Tadaaki Ohtani

Takuya Shitsuta

Kenji Watanabe

Hitoshi Nagao

Kenji Ohnishi

Yasuo Harada

Hironori Tsutsui

Masatoshi Iida

Norikazu Hashimoto

Kumi Higuchi

Shun Otsuji

Shuji Matsumura

Hideaki Satou

The present invention provides novel benzazepine compounds of Formula (1), or salts thereof, having vasopressin Vand Vantagonisms, and medical uses thereof. In the formula, Ris optionally substituted Calkyl, etc.; L is &#x2014;C(&#x2550;O)&#x2014;NH&#x2014;, etc.; Ring Ais a hydrocarbon ring, etc.; Ring Ais a hydrocarbon ring, etc.; and each of Rings Aand Amay have at least one substituent.

Benzazepine derivatives

The present invention provides novel benzazepine compounds of Formula (1), or salts thereof, having vasopressin Vand Vantagonisms, and medical uses thereof. In the formula, Ris optionally substituted Calkyl, etc.; L is &#x2014;C(&#x2550;O)&#x2014;NH&#x2014;, etc.; Ring Ais a hydrocarbon ring, etc.; Ring Ais a hydrocarbon ring, etc.; and each of Rings Aand Amay have at least one substituent. 

An object of the present invention is to provide a novel benzazepine compound or a salt thereof, which has excellent vasopressin antagonistic activity. The benzazepine compound or a salt thereof of the present invention is represented by Formula (1): wherein R, Rand Rmay be the same or different and each represents H or D; and Rand Reach represents a Calkyl group, a Cdeuteroalkyl group, or a Cperdeuteroalkyl group.

Benzazepine compound

The present invention provides a heterocyclic compound represented by General Formula (1):  

Heterocyclic compound and pharmaceutical composition thereof

An object of the present invention is to provide a medicinal drug much improved in anti tumor activity and excellent in safety. According to the present invention, there is provided a medicinal drug containing a compound represented by the following general formula (1) or a salt thereof as an active ingredient: [Formula 1] wherein Xrepresents a nitrogen atom or a group &#x2014;CH&#x2550;, Rrepresents a group &#x2014;Z&#x2014;R, in which Z represents a group &#x2014;CO&#x2014;, a group &#x2014;CH(OH)&#x2014; or the like, Rrepresents a 5- to 15-membered monocyclic, dicyclic or tricyclic saturated or unsaturated heterocyclic group having 1 to 4 nitrogen atoms, oxygen atoms or sulfur atoms, Rrepresents a hydrogen atom or a halogen atom, Y represents a group &#x2014;O&#x2014;, a group &#x2014;CO&#x2014;, a group &#x2014;CH(OH)&#x2014; or a lower alkylene group, and A represents [Formula 2] wherein Rrepresents a hydrogen atom, a lower alkoxy group or the like, p represents 1 or 2, Rrepresents an imidazolyl lower alkyl group or the like. 

Diarylether derivatives as antitumor agents

The present invention provides a novel compound, which has an excellent effect of suppressing the generation of collagen and less side effects, with being excellent in terms of safety. The compound of the present invention is represented by the following general formula (1): [wherein Xrepresents a nitrogen atom or a group &#x2014;CH&#x2550;; Rrepresents a group &#x2014;Z&#x2014;R, wherein Z represents a group &#x2014;CO&#x2014;, a group &#x2014;CH(OH)&#x2014;, or the like, and Rrepresents a 5- to 15-membered monocyclic, dicyclic, or tricyclic, saturated or unsaturated heterocyclic group having 1 to 4 nitrogen atoms, oxygen atoms, or sulfur atoms; Rrepresents a hydrogen atom, a halogen atom or a lower alkylene group; Y represents a group &#x2014;O&#x2014;, a group &#x2014;CO&#x2014;, a group &#x2014;CH(OH)&#x2014;, a lower alkylene group, or the like; and A represents a group or the like, wherein Rrepresents a hydrogen atom, a lower alkoxy group, or the like, p represents 1 or 2, and Rrepresents an imidazolyl lower alkyl group or the like.

Aromatic compounds for suppressing the generation of collagen

Benzoheterocyclic derivatives

Benzazepine derivatives with vasopressin agonistic activity

Novel benzoheterocyclic compound of the formula (1): ##STR1## and pharmaceutically acceptable salts thereof, which show excellent anti-vasopressin activity and oxytocin antagonistic activity, and are useful as a vasopressin antagonist or oxytocin antagonist.

Benzoheterocyclic compounds

Benzoazepinyl compounds as oxytocin and vasopressin antagonists

Growing community of inventors

Osaka, Japan

Keizo Kan