University of Southern California

Biovinc LLC

University of California

Keivan Sadrerafi

Frank Hallock Ebetino

Charles E McKenna

Shuting Sun

Mark Walden Lundy

Ichiro Nishimura

Akishige Hokugo

Eric T Richard

Philip T Cherian

Parish Sedghizadeh

Philip Cherian

Described herein are bisphosphonate oxazolidinone compounds, and conjugates and pharmaceutical formulations thereof, that can include a bisphosphonate and an oxazolidinone (or an oxazolidinone antimicrobial or antibiotic agent, substituent or derivative thereof), where the oxazolidinone can be releasably coupled to the bisphosphonate. Also provided herein are methods of making and methods of using the bisphosphonate oxazolidinone compounds, conjugates and pharmaceutical formulations thereof. Also provided herein are methods of use of the compounds, conjugates and formulations for treating a bone disease or for use in preparing a formulation for the treatment a bone disease.

Bone targeted antimicrobial oxazolidinone related compounds, formulations thereof, and uses thereof

Described herein are bisphosphonate quinolone compounds, conjugates and pharmaceutical formulations thereof that can include a bisphosphonate and a quinolone, where the quinolone can be releasably coupled to the bisphosphonate. Also provided herein are methods of making and methods of using the bisphosphonate quinolone compounds, conjugates and pharmaceutical formulations thereof.

Bisphosphonate quinolone conjugates and uses thereof

Disclosed herein are methods and compositions for removing or displacing bisphosphonates in skeletal tissue.

Skeletal removal of bisphosphonates

Growing community of inventors

Pasadena, CA, United States of America

Keivan Sadrerafi