Columbia University

Epibone, Inc.

Nasal Medical Limited

Keith Yeager

Gordana Vunjak-Novakovic

Sarindr Bhumiratana

Warren L Grayson

Anjali Saqi

Kacey Ronaldson

Stephen Ma

Timothy Chen

Samuel K Sia

Molly Lara Flexman

Andreas H Hielscher

Donald O Freytes

Nina Tandon

Curtis D Chin

Yuk Kee Cheung Poh

Mario Matteo Modena

Paolo Cadinu

Robert Houghtaling

Tassaneewan Laksanasopin

Qun Wan

Tiffany Guo

Amandine Godier-Furnémont

George Eng

Jeisun Shi Xie

Robert Maidhof

Fanxing Meng

Martin O'Connell

Martin O'connell

A cardiac organoid containing 3-D matter of adult human heart tissue.

Engineered adult-like human heart tissue

A system for seeding therapeutic active ingredients (TAIs) onto a porous scaffold includes a first chamber for accommodating the scaffold, a TAI storage device for storing TAIs, at least one second chamber for storing TAI media, and a gas inlet for receiving gas from a compressed source. A flow circuit is coupled to the first chamber, the TAI storage device, the second chamber and the gas inlet for delivering the TAIs, the TAI media and the gas to the scaffold. A pump pumps at least one of the TAIs, the TAI media and the gas in the flow circuit. The system also includes a processor that regulates the delivery of the TAIs, the TAI media and the gas to the scaffold via a plurality of valves.

System and method for seeding and culturing

A medical apparatus having an elongate tubular body with a proximal end, an opening at the proximal end, and a distal end defining an interior space therebetween and the distalmost end of the elongate tubular body is configured to matingly engage a filter assembly; a filter assembly configured to matingly engage the distal portion of the elongate tubular body and to provide a seal with the interior space thereof, the filter assembly comprising a filter membrane and a border that is sectionable for mounting on a slide for analysis on a microscope; and a base member configured to releasably engage the distalmost end of the elongate tubular body and to receive the filter assembly therein.

Medical apparatus and method for collecting biological samples

An anatomically-shaped, human bone graft may be cultivated ex vivo using a bioreactor capable of perfusing large complex porous scaffolds. Scaffolds derived from image-based modeling of a target are seeded with human mesenchymal stem cells and cultivated. A bioreactor configured to house complex three-dimensional scaffold geometries provides controlled flow for perfusion of the cells. Dense uniform cellular growth can be attained throughout the entire scaffold as a result of the medium perfusion. In an embodiment, the bioreactor has a mold into which perfusion medium is pumped under pressure and multiple ports through which the medium exits the mold.

Method of making a personalized bone graft

A medical apparatus and method of preparing one or more cell blocks. The medical apparatus comprises at least one elongate tubular body having a proximal end and a distal end and filter assembly comprising a filter membrane and a border configured to engage the tubular body. The filter membrane and the border are each formed from material that is sectionable.

A bioreactor is provided that permits engineering of multiple different tissues. The bioreactor has a series of flow paths that permit application of tissue-specific media while simultaneously innervating the various different tissues with a common media. The flow paths for the various medias are designed to prevent mixing of the various media as they simultaneously innervate the tissue.

Bioreactor system for engineering tissues

A perfusion bioreactor chamber for engineering a broad spectrum of tissues. The bioreactor allows controlled distribution of fluid through or around scaffolding materials of various shapes, structures and topologies during prolonged periods of cultivation.

Perfusion bioreactor with tissue flow control and live imaging compatibility

Tissue engineering system for making personalized bone graft

Diagnostic systems, methods, and devices employing low-cost handheld components are disclosed herein. A diagnostic system can include a diagnostic device that is configured to perform one or more assays on a fluid sample, such as a whole blood sample, in one or more microfluidic channels or chambers. The diagnostic device can move the fluid sample into or through the one or more microfluidic channels or chambers without using any electrical power, for example, using manual actuation to generate a positive or negative pressure within the diagnostic device. The diagnostic device can have a connector for interfacing with a separate handheld unit that can provide power and data processing. For example, the separate handheld unit can be a smartphone or PDA, and the connector can interface with an existing input/output port of the unit to draw power and/or transmit data.

Diagnostic devices, systems, and methods

A nasal apparatus which is placed in a nostril in order to provide several respiratory benefits includes a nasal insert having a hub, a plurality of arched legs, and a lateral face. Each of the plurality of arched legs comprises a proximal end and a free end positioned opposite each other, wherein the proximal end is adjacently connected to the hub. The plurality of arched legs is positioned around the hub forming a nasal shell structure in the shape of an inner nasal surface of the nostril, wherein the nasal insert is flexible as to apply pressure to the inner nasal surface. The nasal apparatus may further include a bridge and a subsequent nasal insert, wherein the bridge is adjacently connected to both the nasal insert and the subsequent nasal insert, and is positioned in between the nasal insert and the subsequent nasal insert.

Nasal dilator

An imaging interface for diffuse optical tomography of breast includes a plurality of concentric rings. Each concentric ring can include a plurality of optical input/output apertures arranged on a radially inner surface thereof. The rings can have different inner and outer diameters from each other and can be arranged in a stacked configuration. The rings can translate independently of each other along a central axis of the stack. During imaging the breast is inserted into an inner region of the stacked rings. The rings can be translated such that the optical input/output apertures are brought into touch contact (i.e., non-compressing contact) with the surface of the breast, so as to accommodate different size breasts. The rings may be translated such that the spacing between adjacent rings is increased for large breasts and reduced for smaller breasts. Rings may be removed or additional rings added to further accommodate additional breast sizes.

Interfacing systems, devices, and methods for optical imaging

A medical apparatus and method of preparing one or more cell blocks. The medical apparatus comprises at least one elongate tubular body having a proximal end and a distal end and a filter membrane disposed between the proximal end and a distal end of the elongate tubular body. The filter membrane, which can include alignment features and structural features to engage the tubular body, and/or cover, is sectionable. In other embodiments, a valve is provided for opening and closing fluid communication with the filter membrane.

Growing community of inventors

Jersey City, NJ, United States of America

Keith Yeager