Novartis Ag

Nektar Therapeutics

Biomedicines, Inc.

Keith Washco

Danforth Miller

Alan Kugler

Theresa D Sweeney

Richard Malcolmson

Thomas E Tarara

David Lechuga-Ballesteros

Richard E Jones

Sarvajna Kumar Dwivedi

Michael A Eldon

Richard Maskiewicz

Sarma Duddu

Kathleen V Roskos

Trixie Tan

Srinivas Palakodaty

George Trager

Christopher Frantz

The present invention comprises compositions and formulations comprising amphotericin B, compositions and formulations comprising amphotericin B with one or more excipients, methods of making amphotericin B compositions and formulations, as well as systems for using amphotericin B compositions and formulations. Also provided are pharmaceutical compositions comprising the formulation, methods of administering the pharmaceutical compositions and methods of treating patients with the pharmaceutical compositions.

Compositions comprising amphotericin B, mehods and systems

A composition includes particles including at least about 95 wt % of amphotericin B, wherein the particles have a mass median diameter ranging from about 1.1 &#x3bc;m to about 1.9 &#x3bc;m. Another composition also includes particles including at least about 95 wt % of amphotericin B, wherein at least about 80 wt % of the particles have a geometric diameter ranging from about 1.1 &#x3bc;m to about 1.9 &#x3bc;m. Yet another composition includes particles including amphotericin B, wherein the particles have a mass median diameter less than about 1.9 &#x3bc;m, and wherein the amphotericin B has a crystallinity level of at least about 20%. Unit dosage forms, delivery systems, and methods may involve similar compositions.

Compositions comprising amphotericin B, methods, and systems

Methods and compositions are provided for the treatment of a host suffering from a cellular proliferative disease. In the subject methods, antiproliferative agents are administered in a substantially non-aqueous gel delivery vehicle comprising at least one polar organic solvent in combination with one or more thickening agents. The subject methods and compositions provide for the enhanced efficacy of regionally or locally administered antiproliferative proliferative agents.

Gel delivery vehicles for anticellular proliferative agents

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Fremont, CA, United States of America

Keith Washco