Orasure Technologies, Inc.

Sri International

Cd Diagnostics, Inc.

Stc Technologies Inc.

Keith W Kardos

R Sam Niedbala

Luke V Schneider

James G Kane

Norman A Peppers

Mark J Dyer

David A Zarling

Steve Y Ng

Carl Deirmengian

Gregory W Faris

David E Cooper

Michel J Rossi

Mark Fischl

Mark Emrick

Richard C Birkmeyer

Patrick Kilmartin

Alexander Cameron

Kevin Schiller

Eun Kyung Chung

Jarrett Lee Burton

Brian P Murphy

David R Schiff

Angel Sanjurjo

Peter D Byar

Kai-Hung Lau

John W Scott

Naixiong Jiang

Hans H Feindt

David M Lowe

Marie Johansson

Jess Kimball

Erik Askin

Attila Nemeth

Liqiang Jiang

Giffin Daughtridge

William Eric Ross

Daniel Gary Shenberger

Paul Lam Corstjens

Hans J Tanke

Michel Zuiderwijk

Vijay K Mokkapati

Robert T Rewick

Naheed Mufti

Victor Wong

Anastasia Canizales

Dean Fritch

Kristen Blum

Sheena Nonnemacher

Jeremy Savage

Mike Savard

Developer solution vial

The invention provides novel compounds, reagents, systems, and methods for detecting a metabolite related to a NRTI in a biological sample, and use thereof in monitoring adherence to pre-exposure prophylaxis or anti-retroviral treatment. Such reagents comprise NRTI derivatives, analogs, NRTI derivatives conjugates, along with antibodies directed to same, which are useful for anti-body-based methods, such as a lateral flow immunoassay and other point of care devices.

Products and methods for monitoring adherence to nucleoside reverse transcriptase inhibitor therapy

Direct sample collection pad

The invention provides methods and systems for detecting a biomarker in a synovial fluid wherein the system also includes a control to ensure that the test sample is indeed synovial fluid. The biomarkers and the control for synovial fluid can be identified using proteomic methods, including but not limited to antibody based methods, such as an enzyme-linked immunosorbant assay (ELISA), a radioimmunoassay (RIA), or a lateral flow immunoassay.

System for detecting infection in synovial fluid

Fluid sample collection device

A cryosurgery device for dispensing a liquid refrigerant from a container having a valve stem extending outwardly therefrom. The device includes an actuator adapted to seat on the valve stem of the container in order to depress the valve stem to release the refrigerant from the container. The actuator includes an inner passageway having opposed ends disposed therein, one of the ends of the passageway being in fluid communication with the valve stem. An applicator tube is mounted to the actuator at the other end of the inner passageway. A cap is disposed on the top of the container. The actuator is movably positioned on the cap and a shield is attached to the cap to completely receiving the applicator tube. Liquid refrigerant can only be dispensed when the actuator is positioned properly and the applicator tube is disposed within the shield means.

Cryosurgical device and method for cooling surfaces

A lateral flow test strip for the analysis of a sample featuring numerous capture zones arranged in an array such that each capture zone is substantially equidistant from the sample containing area. The sample does not pass through another capture zone to reach any one of the other capture zones. The capture zones are preferably arranged in a linear array perpendicular to the flow of the sample through the lateral flow test strip. The lateral flow test strip allows for an increased number of simultaneous analyses of numerous analytes from one sample to occur on one lateral flow test strip.

Lateral flow assay device with multiple equidistant capture zones

The invention provides methods, compositions, and apparatus for performing sensitive detection of analytes, such as biological macromolecules and other analytes, by labeling a probe molecule with an up-converting label. The up-converting label absorbs radiation from an illumination source and emits radiation at one or more higher frequencies, providing enhanced signal-to-noise ratio and the essential elimination of background sample autofluorescence. The methods, compositions, and apparatus are suitable for the sensitive detection of multiple analytes and for various clinical and environmental sampling techniques.

Up-converting reporters for biological and other assays

The invention relates to a method for producing activated, substantially monodisperse, phosphorescent particles and particles formed thereby. The method suspends substantially monodisperse, phosphor-precursor particles in a fluidizing gas and then introduces a reactive gas to contact the suspended phosphor-precursor particles. Heating the suspended phosphor-precursor particles to a reaction temperature then forms unactivated phosphorescent particles. In another embodiment, the phosphor-precursor particles may be heated to a reaction temperature where they decompose to form the unactivated phosphor particles. The unactivated phosphorescent particles suspended within the fluidizing gas are activated by heating the unactivated phosphorescent particles to an activation temperature forming activated, substantially monodisperse, phosphorescent particles.

Production of substantially monodisperse phosphor particles

A solution-based assay for determining the presence of peroxidatively-active substance in a bodily fluid is described. The solution-based assay contains a spectrophotometric substrate, a hydroperoxide, a pH 6.0-7.0 buffer, a surfactant, and a solvent such as DMSO, THF, DMF, or mixtures thereof, with the balance of the solution being water. The solution-bascd assay is particularly useful in qualitative and quantitative assays for urinary hemoglobin. Solution-based assay kits and assay methods are also described.

Solution-based assay for peroxidatively-active substances in bodily

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Bethlehem, PA, United States of America

Keith W Kardos