Bristol-myers Squibb Compnay

Baxter International Inc.

Ohmeda Pharmaceutical Products Division Inc.

Keith Ramig

John J Venit

Paul Alan Jass

Ramesh N Patel

Ronald L Hanson

John L Dillon, Jr

Sushil K Srivastava

Mark D Schwinden

Saibaba Racha

Wen-sen Li

David R Kronenthal

Laszlo J Szarka

Jollie D Godfrey, Jr

Nachimuthu Soundararajan

Steven L Goldberg

Ralph A Lessor

Linas V Kudzma

Gerald L Powers

Atul S Kotnis

Mary Jo Donovan

William John Winter

Jerome L Moniot

Shawn K Pack

James H Simpson

Leonid A Rozov

Shankar Swaminathan

Chien-Kuang Chen

Substituted alkylketo compounds and process

Processes for stereoselective enzymatic conversion of certain keto carboxylic acid derivatives to form the corresponding alkylamino acid compounds are described. The invention also concerns an engineered yeast host cell containing recombinant nucleic acid capable of expressing a phenylalanine dehydrogenase, as well as an engineered host cell containing recombinant nucleic acid capable of expressing a phenylalanine dehydrogenase enzyme and nucleic acid capable of expressing a formate dehydrogenase enzyme.

Stereoselective reductive amination of ketones

Preparation of (S)-2-amino-6,6-dimethoxyhexanoic acid methyl ester via novel dioxolanes

Preparation of (s)-2-amino-6,6-dimethoxyhexanoic acid methyl ester via novel dioxolanes

N-protected-L-homocysteine disulfide of the formula ##STR1## or an activated form thereof is reacted with (S)-2-amino-6,6-dimethoxyhexanoic acid, methyl ester to give the disulfide intermediate of the formula ##STR2## Cleavage of the disulfide bond followed by acid catalyzed cyclization produces the N-protected lactam of formula III which is useful for preparing the pharmaceutically active compound omapatrilat.

Preparation of

A method of preparing fluoromethyl 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ether (sevoflurane) and structurally related monofluoromethyl ethers in which the monochloromethyl ether precursor thereof is reacted with a sterically hindered tertiary amine hydrofluoride salt.

Method of preparing monofluoromethyl ethers

This invention pertains to methods for preparing 5-aroyl-1,2-dihydro-3H-pyrrolo-[1,2-a]pyrrole-1-carboxylic acids represented by formula (I): ##STR1## In a first embodiment, the method comprises the sequential steps of cyclizing, via a free radical ring closure reaction, and hydrolyzing a compound represented by formula (IV): ##STR2## wherein R.sub.1 is lower alkyl. In a second embodiment, the method comprises the sequential steps of hydrolyzing and decarboxylating a compound represented by formula (VIII): ##STR3##

Methods for preparing

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Orange, NJ, United States of America

Keith Ramig