Closure Medical Corporation

Hyperbranch Medical Technology, Inc.

Ethicon, Gmbh

Keith R D'Alessio

Anthony S Voiers

Mark W Grinstaff

Michael A Carnahan

Kenneth E Stockman

Gary F Prokop

Jeffrey G Clark

Upvan Narang

Leonard F Czuba

Joe B Barefoot

Peter J Kopec

Lawrence H Mainwaring

Julian A Quintero

Ibraheem T Badejo

Daniel L Hedgpeth

Timothy P Hickey

William M Cotter

Gabriel N Szabo

Andres Rivera

Carl E Behrend

Christopher Ryan Yahnker

John Mott Goodman

Tomas Matusaitis

Matthew Justin Morton

Jerry Y Jonn

Roy Keller Thompson

Wai Ngai Chin

Eric J Boone

Todd Taylor

Michael F Brady

Anthony J Sherbondy

John L Manhard

Wendy Y Su

Jared Daniel Goodnow Butlin

Stephen William Cline

Robert Colonna

John F Goodman

Roy R B Attride

Michelle Knotts

Scott A Keplinger

Carl F Behrend

Daniel J Tomko

William F Johnson, Jr

John Conn

Cheryl A Kennedy

Jared DG Butlin

Jr William F Johnson

One aspect of the present invention generally relates to methods of sealing a wound or tissue plane or filling a void splace. In a preferred embodiment, the wound is an ophthalmic, pleural or dural wound. In certain instances, the compositions used to seal the wound or tissue plane comprises a polyalkyleneimine. In a preferred embodiment, the polyalkyleneimine is polyethyleneimine. Treatment of the polyethyleneimine with a cross-linking reagent causes the polyethyleneimine polymers to polymerize forming a seal. In certain instances, the cross-linking reagent is a polyethylene glycol having reactive terminal groups. In certain instances, the reactive terminal groups are activated esters, such as N-hydroxy succinimide ester. In certain instances, the reactive terminal groups are isocyanates. In certain instances, the polyethyleneimine has a lysine, cysteine, isocysteine or other nucleophilic group attached to the periphery of the polymer. In certain instances, the polyethyleneimine is mixed with a second polymer, such as a polyethylene glycol containing nucleophilic groups. In certain instances, the compositions used to seal the wound or tissue plane are formed by reacting a polyalkyleneimine bearing electrophilic groups with a cross-linking reagent containing nucleophilic groups. In certain instances, the electrophilic groups on the polyalkyleneimine are activated esters, such as N-hydroxy succinimide ester. In certain instances, the compositions used to seal the wound or tissue plane are formed by reacting a polyalkyleneimine bearing photopolymerizable groups with ultraviolet or visible light. Compositions used to seal the wound which contain PEI or a derivative of PEI are found to adhere tightly to the tissue. Other aspects of the present invention relate to methods of filling a void of a patient or adhering tissue. In certain instances, the methods use a polyalkyleneimine. In a preferred embodiment, the polyalkyleneimine is polyethyleneimine. Another aspect of the present invention relates to a polymeric composition formed by exposing a polyalkyleneimine to an activated polyalkylene glycol. In certain instances, the composition is attached to mammalian tissue.

Crosslinked gels comprising polyalkyleneimines, and their uses as medical devices

One aspect of the present invention generally relates to methods of sealing a wound or tissue plane or filling a void splace. In a preferred embodiment, the wound is an ophthalmic, pleural or dural wound. In certain instances, the compositions used to seal the wound or tissue plane comprises a polyalkyleneimine. In a preferred embodiment, the polyalkyleneimine is polyethyleneimine. Treatment of the polyethyleneimine with a cross-linking reagent causes the polyethyleneimine polymers to polymerize forming a seal. In certain instances, the cross-linking reagent is a polyethylene glycol having reactive terminal groups. In certain instances, the reactive terminal groups are activated esters, such as N-hydroxy succinimide ester. In certain instances, the reactive terminal groups are isocyanates. In certain instances, the polyethyleneimine has a lysine, cysteine, isocysteine or other nucleophilic group attached to the periphery of the polymer. In certain instances, the polyethyleneimine is mixed with a second polymer, such as a polyethylene glycol containing nucleophilic groups. In certain instances, the compositions used to seal the wound or tissue plane are formed by reacting a polyalkyleneimine bearing electrophilic groups with a cross-linking reagent containing nucleophilic groups. In certain instances, the electrophilic groups on the polyalkyleneimine are activated esters, such as N-hydroxy succinimide ester. In certain instances, the compositions used to seal the wound or tissue plane are formed by reacting a polyalkyleneimine bearing photopolymerizable groups with ultraviolet or visibile light. Compositions used to seal the wound which contain PEI or a derivative of PEI are found to adhere tightly to the tissue. Other aspects of the present invention relate to methods of filling a void of a patient or adhering tissue. In certain instances, the methods use a polyalkyleneimine. In a preferred embodiment, the polyalkyleneimine is polyethyleneimine. Another aspect of the present invention relates to a polymeric composition formed by exposing a polyalkyleneimine to an activated polyalkylene glycol. In certain instances, the composition is attached to mammalian tissue.

Provided is an extended length, flexible or bendable spray tip assembly for use with a multi-component surgical sealant. The tip assembly is particularly suited for use in surgical procedures having limited access to a surgical field, for example, neurosurgical procedures involving infratentorial, skull base, or transsphenoidal craniotomy, as well as the spine. The tip assembly can be used in combination with a multi-component delivery system or applicator.

Extended tip spray applicator for two-component surgical sealant, and methods of use thereof

Aspects of the invention relate to an applicator, and methods of use thereof, which can house multiple component formulations in separate material receptacles, which components can then be easily combined at the time of use without assembly by the user. In certain embodiments, a device of the invention can be used for, but is not limited to, applying hydrogel formulations to dura mater, abdominal tissue in hernia repair, tissues near the spine, lung tissue, intestinal tissue, or any of the internal tissues. In certain embodiments, a device of the invention can be configured to apply a spray or a stream of a liquid formulation to a surface. In certain embodiments, a device of the invention can be configured to deliver the formulation through an endoscope or laparoscope.

Self-contained medical applicators for surgical sealants, and methods of use thereof

Certain aspects of the invention relate to an applicator, and methods of use thereof, which can house multiple component formulations in separate material receptacles, which can then be easily reconstituted at time of use without any assembly by the user. A device of the invention can be used for, but is not limited to, applying hydrogel formulations to dura mater, abdominal tissue in hernia repair, tissues near the spine, lung tissue, intestinal tissue, and any of the internal tissues. A device of the invention can be configured to apply a spray or a stream of liquid formulation onto a surface to be treated. A device of the invention can be configured to deliver the formulation through an endoscope or laparoscope.

Self-contained medical applicators for multiple component formulations, and methods of use thereof

One aspect of the invention relates to an applicator system, and methods of use thereof, that can be used to house separately one or more liquids and one or more solids (e.g., components of a polymerizable hydrogel). In certain embodiments, the applicator systems are further designed to facilitate the mixing of the solids and liquids inside the applicator. In addition, in certain embodiments, the applicator systems are also designed to facilitate the application of the mixture to a surface.

Applicators for multiple component formulations and the like, and methods of use thereof

An applicator/dispenser for dispensing, mixing and/or applying a polymerizable monomeric adhesive or sealant material comprises: a body portion; an actuator movable relative to the body portion; a cavity in the body portion; and a piercing or breaking portion on the actuator. Movement of the actuator relative to the body portion moves the piercing or breaking portion into the cavity. When a container of adhesive or sealant material is at least partially disposed within the cavity, movement of the actuator relative to the body portion moves the piercing or breaking portion to rupture the container for mixing, dispensing and/or applying the adhesive or sealant material.

Applicators, dispensers and methods for mixing, dispensing and applying adhesive or sealant material and another material

A package assembly or kit can be used in conjunction with storing and dispensing adhesive materials. The package assembly can include an enclosure in which an applicator and a container may be positioned. The container contains adhesive material. The enclosure may include a base and a cover. The base preferably includes one or more cavities, with at least one applicator disposed in one of the cavities. Further, the container may be disposed in another of the cavities. The cover may be provided with a plurality of wells. The container may include a restrictor positioned within a neck of the container. The restrictor is provided to limit the volume of adhesive material retained in an absorbent end of an applicator such as a swab. The package assembly can be provided in a sterilized condition.

Package assembly with applicator and container for adhesive materials

A container made without employing a mold release agent, comprised of halogenated polymeric material provides an extended shelf-life for 1,1-disubstituted ethylene adhesive monomer compositions.

Halogenated polymeric containers for 1, 1-disubstituted monomer compositions

An applicator for dispensing adhesive material includes a container body holding the adhesive material and an applicator tip configured to permit improved control and economy in application of the adhesive.

Adhesive applicators with improved applicator tips

An applicator for dispensing adhesive material, includes a container body, and an applicator tip, where the adhesive material is located in the container body in a non-contacting relationship with the applicator tip prior to dispensing said adhesive material. The applicator tip has a proximal open end open toward said container body for attachment to the container body, a distal end having at least one orifice, a restrictive flow portion located between the proximal end and the distal end, and a flow reducing portion located between the restrictive flow portion and the distal end. The applicator tip defines a fluid flow channel from the proximal end to the distal end and through the restrictive flow portion and the flow reducing portion, where the applicator tip permits the adhesive material to pass through the applicator tip and exit the applicator tip at the at least one orifice.

Adhesive applicator with improved applicator tip

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Cary, NC, United States of America

Keith R D'Alessio