Cornell University

University of Utah Research Foundation

Keith Purpura

Nicholas D Schiff

Steven F Kalik

Jonathan Baker

Jae-Wook Ryou

Andrew Janson

Nicholas Schiff

Christopher Butson

A method for selective activation of central thalamus fibers in a subject is disclosed. The method involves providing one or more electrodes each with one or more contacts. The one or more electrodes are positioned in the subject's central thalamus fibers. An electrical stimulus is applied to the positioned one or more electrodes to selectively activate the central thalamus fibers of the subject. The positioning and applying are carried out to maximize central lateral nucleus and medial dorsal tegmental tract fiber pathway activation in the subject and to minimize central median parafascicularis fiber pathway activation in the subject. Methods, devices, and computer readable media for surgical planning involving selective activation of central thalamus fibers in a subject are also disclosed.

Methods for selective activation of central thalamus fibers in a subject and systems therefor

The present invention relates to a method to control a thalamic projecting fiber in a subject. This method involves providing a subject having a first stimulator and a second stimulator implanted in the subject's central thalamus. A stimulus signal generator is provided which is coupled to the first and second stimulators. Separate stimulus signals are provided from the stimulus signal generator to the first and second stimulators under conditions effective to control the thalamic projecting fiber in the subject. Also disclosed is an apparatus for deep brain stimulation.

System and methods for multi-site activation of the thalamus

Disclosed is a method for improving cognitive function or for improving coordination of function across a patient's cortical regions. The method includes applying electrical stimulation to at least a portion of the patient's subcortical structures involved in the generation and control of generalized efference copy signals. Internally generated movement of the patient is then detected and, in response to such internally generated movement, application of electrical stimulation is controlled. The method of the present invention has a number of benefits, including increasing flexibility in identifying targets for stimulation, improving the probability of successfully treating brain injury, and permitting patient biofeedback and self-regulation.

Feedback method for deep brain stimulation with detection of generalized efference copy signals

Feedback mechanism for deep brain stimulation

Growing community of inventors

New York, NY, United States of America

Keith Purpura