Selventa, Inc.

Genstruct, Inc.

Keith O Elliston

Dexter Roydon Pratt

William M Ladd

Eric K Neumann

Justin Sun

Joseph J Loureiro

Ted M Slater

D Navin Chandra

Fatima Chandra, Legal Representative

The invention relates to computational methods, systems and apparatus useful in the analysis of sets of biomolecules in an accessible body fluid or tissue sample from a patient, which biomolecules collectively or individually are candidates to serve as biomarkers, i.e., biomolecules which together or individually upon detection or change are indicative that the patient is in some biological state, such as a diseased state. The methods permit one to examine such potential biological markers to determine whether each one is indeed present as a consequence of the biological state, or as an artifact of the biomarker search protocol.

Computer-aided discovery of biomarker profiles in complex biological systems

Method and system for managing and evaluating life science data. Life Science data is placed in a knowledge base, that may be used for a variety of analysis tasks. Creating a knowledge base from the life science data involves generating two or more nodes indicative of life science data, assigning to one or more pairs of nodes a representation descriptor that corresponds to a relationship between the nodes, and assembling the nodes and the relationship descriptor into a database, such that at least one of the nodes is joined to another node by a representation descriptor. In some embodiments, the representation descriptor includes a case frame that describes the relationships between elements of life science data.

System, method and apparatus for assembling and mining life science data

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Sudbury, MA, United States of America

Keith O Elliston