Glaxo Group Limited

Keith Mills

Ian H Coates

David E Bays

Michael D Dowle

Colin F Webb

Alexander W Oxford

Harry Finch

Eric W Collington

Peter C North

Colin David Eldred

Roger Hayes

David F Woodings

John W Whitehead

The invention relates to a process for the preparation of a compound of formula (I) ##STR1## wherein R represent a hydrogen atom or a methyl or ethyl group, which comprises cyclising a compound of formul (IV) ##STR2## Where R represents a hydrogen atom, the compound of formula (IV) may optionally be alkylated to produce a compound in whcich R is methyl or ethyl. The compound of formula (I) is useful as an intermediate in the preparation of 2,3,4,5-tetrahydro-2-[(imidazol-4(or 5)-yl)methyl]-1H-pyrido[4,3-b]indol-1-ones having 5-HT.sub.3 antagonist activity.

Process for the preparation of lactam derivatives

Compounds are described of the formula (1) ##STR1## where: R.sup.1 is a hydrogen atom or a methyl group;

Aminocyclopentyl ethers and their preparation and pharmaceutical

A process is described for the preparation of a compound of formula (1) ##STR1## or a salt thereof, which comprises reacting a compound of formula (2) ##STR2## (where A is a displaceable atom or group and R is a hydrogen atom or a C.sub.1-6 alkyl or C.sub.7-20 aralkyl protecting group) or a salt thereof, to replace the moiety A with a phenyl group, followed where necessary by removal of a C.sub.1-6 alkyl or C.sub.7-20 aralkyl protecting group and/or by salt formation. The replacement of A in formula (2) by a phenyl group may be effected with a compound PhX (3) wherein Ph represents a phenyl and X is an atom or group as defined for A in formula (2) or X is a metal atom or metal-containing group or a group SiR'.sub.3 (where R' is an alkyl or aryl group) provided that when A is --B(OH).sub.2 X can only represent a conventional leaving group.

Preparation of a piperidinylcyclopentylheptenoic acid derivative

Compounds are disclosed of formula (I): ##STR1## wherein R.sub.1 is halogen, a C.sub.1-3 alkoxy, R.sub.6 R.sub.7 NCO(CH.sub.2).sub.p --, R.sub.6 CONH(CH.sub.2).sub.p --, R.sub.6 R.sub.7 NSO.sub.2 (CH.sub.2).sub.p --, or R.sub.8 SO.sub.2 NH(CH.sub.2).sub.p -- (where R.sub.6 and R.sub.7 each represents hydrogen or C.sub.1-3 alkyl, R.sub.8 represents C.sub.1-3 alkyl and p is zero or 1);

Indole derivatives

Compounds are disclosed of formula (I) ##STR1## wherein R.sub.1 represents CHO, COR.sub.8, CO.sub.2 R.sub.8, CONR.sub.9 R.sub.10, CSNR.sub.9 R.sub.10 or SO.sub.2 NR.sub.9 R.sub.10, where

5-substituted 3-aminoalkyl indoles useful in treatment of migraine

Compounds are disclosed of general formula (I) ##STR1## wherein R.sub.1 represents an alkyl, cycloalkyl, aryl or aralkyl group;

Growing community of inventors

Ware, United Kingdom

Keith Mills