Massachusetts Institute of Technology

Keith M Forward

Gregory C Rutledge

Won Sik Kim

Trevor Alan Hatton

Bernhardt Levy Trout

Allan Stuart Myerson

Yi Du

Jung-Hoon Chun

Salvatore Mascia

Nikhil Padhye

Emily Chang

Himanshu Hemant Dhamankar

James M B Evans

Ryan Richard Slaughter

Mao Wang

Blair Kathryn Brettmann

James Mb Evans

Disclosed are methods that utilize the differences in physical properties between two coating fluids to form core-shell particles or core-shell fibers by coaxial free-surface electrospinning. The methods are able to achieve higher productivity than known methods, and are tunable. Nonwoven fiber mats of electrospun fibers have garnered much scientific and commercial interest in recent years due to their unique properties, such as their high porosity, high surface area and small diameter fibers.

Formation of core-shell fibers and particles by free surface electrospinning

Layer processing for pharmaceuticals, and related systems, methods, and articles are generally described. In some embodiments, ingestible pharmaceutical products (e.g., tablets) can be formed by processing one or more layers containing a pharmaceutically active composition. For example, at least one layer containing a pharmaceutically active composition can be manipulated (e.g., folded, rolled, stacked, etc.) such that the average thickness of the product formed by the manipulation is at least about two times the average thickness of the portions of the layer(s) used to form the product. In some embodiments, after the layer is manipulated, it can be processed (e.g., cut, coated, etc.) to form a final product such as, for example, a tablet.

Layer processing for pharmaceuticals

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Riverside, CA, United States of America

Keith M Forward