Mayo Foundation for Medical Education and Research

University of Washington

Keith L Knutson

Christopher J Krco

Lynn C Hartmann

Kimberly R Kalli

Andrea M Henle

Mary L Disis

John D Fikes

Glenn Ishioka

Tobias Peikert

Patricio Escalante

Melanie Beebe

Richard P Darveau

Robert Reife

This document provides methods and materials related to assessing immunity to folate receptors. For example, methods and materials for assessing FR&#x3b1; immunity in a mammal are provided. This document also provides methods and materials related to stimulating immunity to folate receptors.

Immunity to folate receptors

The present invention provides HLA-DR (MHC class II) binding peptides derived from the ovarian/breast cancer associated antigens, Human Epidermal Growth Factor Receptor 2 (HER-2/neu), Carcinoembryonic Antigen (CEA), Insulin Growth Factor Binding Protein 2 (IGFBP-2), and Cyclin D1. The immunogenic peptides can be used in cancer vaccines.

HLA-DR binding peptides and their uses

This document provides methods and materials for generating CD8T cells having the ability to recognize cancer cells expressing a HER2/neu polypeptide. For example, methods and materials for using a polypeptide consisting of an SLAFLPESFD amino acid sequence in vivo or in vitro to generate CD8T cells having the ability to recognize and lyse cancer cells expressing a HER2/neu polypeptide are provided.

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Methods and materials for generating CD8+ T cells having the ability to recognize cancer cells expressing a HER2/neu polypeptide

This document provides methods and materials related to identifying mammals having a LTBI. For example, methods and materials for using ELISpot assays to identify mammals (e.g., humans) having a LTBI are provided.

Detecting latent tuberculosis infections

The document provides to methods and materials for generating T cells (e.g., antigen-specific CD4T cells). For example, methods and materials for using nested MHC class II epitopes as vaccines to generate activated CD4T cells in vivo or as reagents to generate activated CD4T cells ex vivo are provided.

Methods and materials for generating T cells

A preparation containing lipopolysaccharide (LPS) ofhaving a molecular negative mass ion of 1435 or 1449 is used as an immune system modulator to redirect a host's immune system against an antigen of interest. The 1435/1449 LPS preparation can be isolated fromor prepared as a derivative or mimetic thereof. The immunomodulating preparations of1435/1449 can be used as a vaccine adjuvant, and can be used to stimulate an immune response against a selected antigen associated with a disease of interest, such an antigen associated with a tumor, infectious disease, autoimmune disease, MHC antigen, or to modulate asthma or other inflammatory conditions.

Growing community of inventors

Rochester, MN, United States of America

Keith L Knutson