W. L. Gore & Associates, Inc.

Keith Knisley

Edward H Cully

Edward C Gunzel

Greg Rusch

Lauren Zambotti

Michael J Vonesh

Rachel Radspinner

Jason J Strid

Vishnu T Marla

Paul A Silvagni

The present disclosure relates to implantable encapsulation devices for housing a biological moiety or a therapeutic device that contains a biological moiety. Particularly, aspects of the present disclosure are directed to an implantable apparatus that includes a distal end, a proximal end, a manifold including at least one access port positioned either at the distal end or the proximal end, and a plurality of containment tubes affixed to the manifold and in fluid communication with the at least one access port. Additionally, the encapsulation device may contain a flush port and a tube that are fluidly connected to the manifold. The containment tubes may contain therein a biological moiety (e.g., cells) or a therapeutic device (e.g. a cell encapsulation member).

Implantable encapsulation devices

The invention is an improved biocompatible surface for a variety of medical purposes. The biocompatible surface employs a unique tight microstructure that demonstrates enhanced cellular response in the body, particularly when placed in contact with blood. As a blood contact surface, the present invention can be beneficially employed in a wide variety of implantable devices and in many other devices and equipment that come in contact with blood.

Biocompatible surfaces and devices incorporating such surfaces

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Flagstaff, AZ, United States of America

Keith Knisley