G.d. Searle & Company

Pharmacia Corporation

Keith G McCullagh

Leslie D Bell

Alan G Porter

Harry John Wadsworth

Harold Gregory

Described is a new class of polypeptide cell modulators characterized by being composed of two covalently linked cell modulators in a linear polypeptide sequence. Such dual function polypeptides have new and particularly useful activities when the component polypeptide cell modulators are interferons, lymphokines or cytotoxins which act through different and specific cell receptors to initiate complementary biological activities. Also described is a peptide linker segment comprising a mouse IgG gamma &ldquo;hinge&rdquo; in which the four cysteines of the &ldquo;hinge&rdquo; have been converted to serines.

Peptide linkers for covalent linking polypeptide cell modulators

Described is a new class of polypeptide cell modulators characterized by being composed of two covalently linked cell modulators in a linear polypeptide sequence. Such dual function polypeptides have new and particularly useful activities when the component polypeptide cell modulators are interferons, lymphokines or cytotoxins which act through different and specific cell receptors to initiate complementary biological activities.

Covalently linked polypeptide cell modulators such as

Covalently linked polypeptide cell modulators

Pharmaceutical compositions for oral administration comprise human urogastrone or a urogastrone fragment as active ingredient and such an active ingredient may be used for the manufacture of a medicament for promoting healing of a damaged alimentary tract.

Duodenal and gastric ulcer treatment with oral urogastrone

This invention encompasses novel carboxyalkyl peptide derivatives which are collagenase inhibitors.

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Princes Risborough, United Kingdom

Keith G McCullagh