R.p.scherer Technologies, Inc.

R.p. Scherer Corporation

R. P. Scheier Company

Keith Edward Tanner

Elizabeth Youngblood

Rickey S Shelley

Stephen W Burnett

Norman S Stroud

Peter Robert Draper

John J Getz

Robert Waranis

Gregory A Schurig

Peter Beke

Kelly Orange

Mani Sundararajan

Youchino Wei

Steve Burnett

Frank S S Morton

John L Cain

David Walker

Brian R Pansari

A non-gelatin encapsulation system for liquid filled soft capsules, by nature of the carrier, the cationic-ionic balance of the carrier and the active ingredients, or the concentration of the active ingredients and excipients, are difficult or impossible to commercially encapsulate in gelatin capsules. In particular, the system is adapted for the encapsulation of highly basic, or alkaline, fills. The system provides for a predominantly starch and gelling carrageenan based shell, which displays high resistance to both concentrated fills and to alkaline fills, in particular, to those fills which contain the salt or salts of weak acids and strong bases.

Non-gelatin soft capsule system

Disclosed herein are compositions comprising a modified starch and a carrageenan, especially iota-carrageenan, where the compositions are suitable for use in manufacturing soft capsules.

Film forming compositions comprising modified starches and iota-carrageenan and methods for manufacturing soft capsules using same

This invention relates to a method and apparatus for forming soft capsules and provides novel processing flexibility. The apparatus comprises a three-way valve injector wedge. This injector wedge allows for set-up of the encapsulation machine with a placebo fill and quick change over to active fill. This conserves use of the active ingredient.

Encapsulation machine with valved injection wedge

This invention relates to a method and apparatus for forming soft capsules and provides novel processing flexibility. The apparatus includes extrusion dies as an alternative to spreader boxes and the use of melt-on-demand technology to enhance the long term stability of the film-forming materials. Preferred embodiments provide a positive displacement pump to transport the molten film-forming material from the melt-on-demand device to the extrusion device and preferably a reservoir means disposed between said extrusion device and said means to melt said film-forming material. The encapsulation apparatus may also include a valved injection wedge.

Apparatus for manufacturing encapsulated products

Disclosed herein are composition comprising a modified starch and a carrageenan, especially iota-carrageenan, where the compositions are suitable for use in manufacturing soft capsules.

Disclosed are suspensions suitable for encapsulation in gelatin capsules, comprising a solid phase consisting of solid particles having a mean diameter of at least about 149 &mgr;m, and a liquid phase capable of suspending the solid phase, the suspension having a predetermined rheology at a temperature suitable for encapsulation into gelatin capsules.

Soft gelatin capsules containing particulate material

A dosage form for pharmaceuticals, nutrient supplements and food products which is nontoxic and suitable for introduction into mammalian bodies comprising soft elastic gelatin capsule containing a colorless clear liquid carrier and an active ingredient. The capsule is rendered particularly tamper evident by color neutralizing its inherent amber/yellow color with edible dyes and pigments.

Tamper evident pharmaceutical dosage form

A dosage unit form comprises a biologically active agent, such as a pharmaceutical, nutritional supplement or diagnostic, dissolved or suspended in a carrier liquid encapsulated in a soft elastic gel capsule. The carrier liquid comprises maltitol syrup as a major component. Maltitol syrup may be the only component of the carrier liquid, or may be blended with other liquids and/or excipients.

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Safety Harbor, FL, United States of America

Keith Edward Tanner