Durect Corporation

Guilford Pharmaceuticals, Inc.

Eisai Inc.

Keraplast Technologies, Ltd.

Keith Edward Branham

John W Gibson

Jeremy C Wright

James Perry English

Stefania Sjobeck

Zhong Zhao

Christopher M Rubino

Wilma Tamraz

John J Leonard

Donna Hall

Brooks Boyd

Felix T Theeuwes

Mahesh V Chaubal

Su Il Yum

William W Van Osdol

James Matriano

Michael M Sekar

John Tipton

Whitney Moro

Donald R Cowsar

Doug Mink

Reuben Land

Deborah Barnette

The present disclosure generally provides complexes including a pharmaceutically active agent and a functionalized polymer, wherein the functionalized polymer includes repeat units, the repeat units including ionizable repeat units having at least one ionizable side group and/or ionizable end group, a plurality of the at least one ionizable groups forming non-covalent bonds with the pharmaceutically active agent. Polymers which may be used to form such complexes as well as methods of making and using the complexes and related compositions are also provided.

Pharmaceutically active agent complexes, polymer complexes, and compositions and methods involving the same

Compositions may include a pharmaceutical active agent, a high viscosity liquid carrier material (HVLCM), a lactic acid-based polymer, and an organic solvent. Related compositions and methods are also disclosed. For instance, a carrier formulation for controlled release of injectable drugs is disclosed. The formulation may include a non-water soluble high viscosity liquid which may be sucrose acetate isobutyrate, a lactic-acid based polymer which may be a poly(lactic acid)(glycolic acid), and an organic solvent which maintains the composition in a monophasic form at 25&#xb0; C. in one atmosphere. Drug in the formulation may be released upon administration such that less than 10% (e.g. 2-8%) of drug is released in the first 5 hours; 10% to 80% of the drug is released during a period of 5 hours to 7 days after administration; and 10% to 40% of the drug is released gradually over a period of 7 days to 28 days from initial administration. The drug may be an anti-schizophrenia agent delivered by injection.

Compositions and methods involving polymer, solvent, and high viscosity liquid carrier material

Disclosed are formulations and related methods that comprise a non-polymeric, non-water soluble high viscosity liquid carrier material having a viscosity of at least 5,000 cP at 37&#xb0; C. that does not crystallize neat under ambient or physiological conditions; a specified linear polymer comprising lactide repeat units; and one or more solvents that have a solvent capacity.

Depot formulations

Injectable controlled release composition comprising high viscosity liquid carrier

Compositions may include a pharmaceutical active agent, a high viscosity liquid carrier material (HVLCM), a lactic acid-based polymer, and an organic solvent. Related compositions and methods are also disclosed.

The present invention relates to novel phosphorus-containing compounds with polymeric chains, and methods of making and using the same. In part, subject compositions containing phosphorus-containing compounds with polymeric chains and a therapeutic agent, and methods of making and using the same, are described. Certain of the subject compositions exhibit reverse thermal gelation.

Phosphorus-containing compounds with polymeric chains, and methods of making and using the same

Useful materials are produced from keratin containing raw materials by a process that includes gentle lanthionization of cystine disulfide bonds. Hydratable materials are produced for use in medical and cosmetic applications.

Gentle process for conversion of cystine in keratin-containing materials to lanthionine

Phosphorous-containing compounds with polymeric chains, and methods of making and using the same

The present invention provides improved processes for purifying polymer preparations by removing contaminants, such as metal contaminants. The present invention also provides improved processes for producing phosphopolymers, which can yield improved polymers in terms of molecular weight, homogeneity, consistency and purity. Polymers and polymer preparations also are provided. The present invention is time, labor and energy efficient, and thus marks an improvement over past approaches.

Polymers and polymerization processes

Growing community of inventors

Pelham, AL, United States of America

Keith Edward Branham