3f Therapeutics, Inc.

Baxter International Inc.

Harbor Medtech, Inc.

Edwards Lifesciences Corporation

Medtronic 3f Therapeutics, Inc.

Medtronic Ats Medical, Inc.

Aws Nashef

Keith Myers

Rodolfo C. Quijano

Keith E Myers

Richard S Rhee

Douglas S Cali

W Jerry Mezger

Can B Hu

Christine Nguyen

Jerry L Jackman

Than Nguyen

Robert J Todd

Robert C Peterson

Carl A Swindle

Victor S Packham

Minh T Ma

Ross Bartholomew

Charles R Weyrauch

Jane Li

Brian Biancucci

Andrzej M Malewicz

Bjarne Bergheim

Delos M Cosgrove, Iii

Diana Nguyen-Thien-Nhon

Aws S Nashef

Rodolfo C Quijano

Jeffrey P Dumontelle

Matthew W Weston

Ralph Kafesjian

David Elizondo

Jason Artof

R C Quijano

Oleg Svanidze

Tuoc Tan Nguyen

Norma L Lowe

William Jerry Mezger

Rodolfo Quijano

David R Elizondo

Tuor Tan Nguyen

Disclosed herein are embodiments of a reinforced collagen matrix device for superior capsule repair. The device can include a collagen matrix cover, a first reinforcement strip positioned along the first side of the cover, and a second reinforcement strip positioned along the second side of the cover. A first end and a second end of the first and second reinforcement strips can extend past the first end and the second end of the collagen matrix cover so as not be covered by the collagen matrix cover. The collagen matrix cover can be folded along a first fold and a second fold and extend over the first and second reinforcement strips so that a portion of the first and second reinforcement strips are covered by the collagen matrix cover along a portion of the length of the first reinforcement strip.

Port-accessible multidirectional reinforced minimally invasive collagen device for soft tissue repair

Degradable bioprostheses made of collagen-based material having amine-based and ester-based crosslinks are provided, as are methods for their formation and use. Some embodiments of the present invention are directed towards a method of controlling the ratio of amine-based crosslinks to ester-based crosslinks within a collagen-based material to provide a tailorably crosslinked collagen-based material. Some embodiments provide a method of making a degradable bioprosthesis involving controlling crosslinking to afford a degradable bioprosthesis that is partially crosslinked. By controlling the ratio of amine-based to ester-based crosslinks, by controlling the level of crosslinking, or by controlling both of these features, degradable bioprostheses with tailored degradation rates can be synthesized. Some embodiments of degradable bioprostheses have degradation rates that are tailored to allow their use in particular medical applications. Some embodiments are directed towards methods of use degradable bioprostheses in wound healing, tissue repair, and tissue supplementation.

Crosslinked human or animal tissue products and their methods of manufacture and use

The present invention provides valve prostheses adapted to be initially crimped in a narrow configuration suitable for catheterization through body ducts to a target location and adapted to be deployed by exerting substantially radial forces from within by means of a deployment device to a deployed state in the target location.

Implantable valve prosthesis

A method and device for reducing paravalvular leakage upon implantation of a replacement heart valve is provided. The valve assembly includes a tissue or bioprosthetic heart valve attached to an anchoring structure. The anchoring structure includes an inlet rim that is substantially C-shaped in cross section to form a concave landing zone. The anchoring structure self-seats when implanted in the sinus of a patient with the proximal and distal ends of the C-shaped inlet rim pushed against the aorta to effectively prevent paravalvular leakage.

Anchoring structure with concave landing zone

A prosthetic heart valve assembly comprises a plurality of leaflets configured to replace the function of a native heart valve. Each leaflet comprises laminar pericardium tissue. Each leaflet has a coaptation edge formed by laser cutting. The tissue layers of each leaflet are fused together along an entire length of the coaptation edge, and tissue adjacent each coaptation edge does not have significant thermal energy damage.

Prosthetic heart valve assemblies

A method of cutting tissue for use as an implantable medical device employs a laser cutting system. The laser cutting system is computer controlled and includes a laser combined with a motion system. The laser precisely cuts segments out of source tissue according to predetermined pattern as designated by the computer. The cutting energy of the laser is selected so that the cut edges of the tissue segments are fused, melted or welded to discourage delamination or fraying, but communication of thermal energy into the segment beyond the edge is minimized to avoid damaging the tissue adjacent the edge.

Method of cutting tissue using a laser

A method of cutting material for use in an implantable medical device employs a plotted laser cutting system. The laser cutting system is computer controlled and includes a laser combined with a motion system. The laser precisely cuts segments out of source material according to a predetermined pattern as designated by the computer. The segments are used in constructing implantable medical devices. The cutting energy of the laser is selected so that the cut edges of the segments are melted to discourage delamination or fraying, but communication of thermal energy into the segment beyond the edge is minimized to avoid damaging the segment adjacent the edge.

Method of laser cutting pericardial tissue for use with an implantable medical device

Method of cutting material for use in implantable medical device

Methods and systems for minimally invasive replacement of a valve. The system includes a collapsible valve and anchoring structure, devices and methods for expanding the valve anchoring structure, adhesive means to seal the valve to the surrounding tissue, a catheter-based valve sizing and delivery system, native valve removal means, and a temporary valve and filter assembly to facilitate removal of debris material. The valve assembly comprises a valve and anchoring structure for the valve, dimensioned to fit substantially within the valve sinus.

Minimally invasive valve replacement system

Growing community of inventors

Lake Forest, CA, United States of America

Keith E Myers