Echo Therapeutics, Inc.

Keith E Krystyniak

Scott C Kellogg

Han Chuang

James P Hurley

Juan P Eslava

Debashis Ghosh

Jon B Taylor

Christopher Labak

Stephen J Perry

Steven Vordenberg

Joseph O St Cyr

Benjamin Glace

Wayne Menzie

Harry Mitchell

Glenn Trainer

James Joseph Kennedy, Iii

Edward McLean

Abrasion device with abrasive tip

Devices, systems, kits and methods for increasing the skin's permeability controlled by measured skin electrical parameter are described herein. They may be used for transdermal drug delivery and/or analyte extraction or measurement. The controlled abrasion device contains (i) a hand piece, (ii) an abrasive tip, (iii) a feedback control mechanism, (iv) two or more electrodes, and (v) an electrical motor. The feedback control mechanism may be an internal feedback control mechanism or an external feedback control. The kit contains the controlled abrasion-device, one or more abrasive tips, optionally with a wetting fluid. The method for increasing the skin's permeability requires applying the controlled abrasion device to a portion of the skin's surface for a short period of time, until the desired level of permeability is reached. Then the abrasion device is removed, and a drug delivery composition or device or an analyte sensor is applied to the treated site.

Skin permeation device for analyte sensing or transdermal drug delivery

Abrasion device with reference ring and abrasive tip

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Chelmsford, MA, United States of America

Keith E Krystyniak