Genzyme Corporation

Keith E Greenawalt

James W Burns

Louis Masi

Julia B Gershkovich

Surgical prostheses and methods of using and making surgical prostheses are disclosed.

Making a soft tissue prosthesis for repairing a defect of an abdominal wall or a pelvic cavity wall

A soft tissue prosthesis for repairing a defect of an abdominal wall or a pelvic cavity wall, comprising: a three-dimensional mesh sheet comprising at least two types of yarn interlooped or intertwined to define at least two layers, wherein one of the at least two layers is substantially non-biodegradable and porous to allow for tissue ingrowth and another of the at least two layers is substantially biodegradable; and an adhesion barrier in the form of a film, foam or gel, the adhesion barrier polymerized to, and entrapping therein, at least some of the yarns of the substantially biodegradable layer, the substantially biodegradable layer making a connection between the adhesion barrier and the substantially non-biodegradable layer to decrease the likelihood of delamination therefrom, the adhesion barrier being an external layer on a first side of the prosthesis and the substantially non-biodegradable layer being an external layer on the side of the prosthesis opposite the first side, the substantially biodegradable layer being positioned between the substantially non-biodegradable layer and the adhesion barrier.

Soft tissue prosthesis for repairing a defect of an abdominal wall or a pelvic cavity wall

Biocompatible compositions comprising polyanionic polysaccharides combined with hydrophobic bioabsorbable polymers as well as methods for making and using the compositions are described.

Compositions containing polyanionic polysaccharides and hydrophobic bioabsorbable polymers

Biocompatible compositions comprising polyanionic polysaccharides such as Hyaluronic Acid combined with hydrophobic bioabsorbable polymers as well as methods for making and using the compositions are described.

Solid, fibrous bioabsorbable hemostatic compositions containing a bioabsorbable polymer and a hemostatic compound, methods for making the hemostatic compositions, and methods for using the hemostatic compositions are disclosed.

Growing community of inventors

Milton, MA, United States of America

Keith E Greenawalt