Dartmouth College

University Health Network

Microwave Imaging Systems Technologies, Inc.

Dartmouth-hitchcock Clinic

Microwave Imaging System Technologies, Inc.

Mary Hitchcock Memorial Hospital, for Itself and on Behalf of Dartmouth-hitchcock Clinic and

Keith Douglas Paulsen

David W Roberts

Paul M Meaney

Brian William Pogue

Songbai Ji

Xiaoyao Fan

Venkataramanan Krishnaswamy

Alexander Hartov

Frederic Leblond

Pablo A Valdes

Brian Campbell Wilson

Alex Hartov

Ryan J Halter

Sohail K Mirza

Richard J Barth, Jr

Edward Martin Godshalk

John B Weaver

Kenneth M Tichauer

Timothy Raynolds

Jonathan T Elliott

Dennis Wirth

Mira Sibai

David M McClatchy, Iii

Greg Burke

Robert W Holt

Scott Christian Davis

Shudong Jiang

Michael Jermyn

Hamid Dehghani

Stephen Chad Kanick

Dax Kepshire

Anthony Taywon Kim

Daqing Piao

Atthar Mirza

Matthew Pallone

Amir H Golnabi

Colin Morehouse Carpenter

Phaneendra K Yalavarthy

Jia Wang

Heng Xu

Roger Springett

Subhadra Srinivasan

Qianqian Fang

Margaret W Fanning

Tina Zhou

Jonathan D Olson

Benjamin Maloney

Andrea Borsic

Samuel Streeter

Alexander T Farkas

William R Warner

Adam J Pattison

Matthew D J McGarry

Neil Epstein

John C Peiffer

Richard J Barth

A patient-specific device for guiding resection of a tumor located in local tissue of a patient includes a locator form and a surgical guidance cue. The locator form has a locator-form surface matching a surface of the local tissue of the patient near the tumor's location when the local tissue is imaged in a preoperative position, such that the locator form, when fit to the surface of the local tissue, restores the local tissue to the preoperative position. The surgical guidance cue is integrally formed with the locator form and based on images including only preoperative images of the local tissue in the preoperative position, to indicate a spatial property of the tumor in the preoperative position.

Systems and methods for guiding tissue resection

An intraoperative stereovision system has a stereo imager configured to provide stereo images at first and second time (iSV0, iSV(n)) to an image processor configured with a computerized mechanical model of a spinal column, the computerized mechanical model configured to model vertebrae as rigid, displaceable, bodies. The image processor is configured to extract an iSV0 surface model from iSV0 and an iSV(n) surface model from the iSV(n); to register these surfaces, and identify differences therefrom. The image processor is configured to adjust the computerized mechanical model according to the identified differences thereby causing the adjusted computerized mechanical model to track the iSV(n) surface model at each of multiple timepoints.

Intraoperative stereovision-based vertebral position monitoring

A method of generating corrected fluorescence data of concentrations of a targeted fluorophore in tissue of a subject includes administering first and second fluorescent contrast agents to the subject, the first contrast agent targeted to tissue of interest, the second agent untargeted. The tissue is illuminated with light of a first stimulus wavelength and first data is acquired at an appropriate emissions wavelength; the tissue is illuminated at a second stimulus wavelength and second data is acquired at a second emissions wavelength associated with the second agent, the first and second emissions wavelength differ. Difference data is generated by subtracting the second data from the first data. A system provides for stimulus and capture at multiple wavelengths, with image storage memory and subtraction code, to perform the method. Corrected data may form an fluorescence image, or is used to generate fluorescence tomographic images.

Method and apparatus for medical imaging using differencing of multiple fluorophores

A system and method for creating a cavity with a drill assembly provides a powered drill shaft assembly having an articulating tip and a position sensor along the drill shaft; a drill motor assembly with a rotational motor, linear actuator, torque sensor, rotation sensor, electrical resistance sensor and a controller unit having a plurality of programs providing user interface and controlling the operation of the powered drill arrangement; a shroud for the drill shaft with a water port; and a computer software package that combines user specifications with sensor data to control activation and displacement of the drill with a user interface, controls the motor for rotational speed and drilling depth, and gives sensor status, and a display displaying status of a drilling procedure and an image from an imaging device, and that is programmable for a set of parameters for a drilling procedure.

System and method for forming a cavity in soft tissue and bone

This invention provides a hand-held stereovision (HHS) system that is an efficient, accurate, and radiation-free imaging device to acquire intraoperative profiles of the exposed spine in prone position. The reconstructed intraoperative stereovision surfaces (iSV) are registered with preoperative CT (pCT; supine position) in a nonrigid fashion to generate updated CT images (uCT) and correct for vertebral posture and alignment changes. Updated CT images are uploaded to a commercial navigation system for surgical navigation.

Hand-held stereovision system for image updating in surgery

A surgical guidance system has two cameras to provide stereo image stream of a surgical field; and a stereo viewer. The system has a 3D surface extraction module that generates a first 3D model of the surgical field from the stereo image streams; a registration module for co-registering annotating data with the first 3D model; and a stereo image enhancer for graphically overlaying at least part of the annotating data onto the stereo image stream to form an enhanced stereo image stream for display, where the enhanced stereo stream enhances a surgeon's perception of the surgical field. The registration module has an alignment refiner to adjust registration of the annotating data with the 3D model based upon matching of features within the 3D model and features within the annotating data; and in an embodiment, a deformation modeler to deform the annotating data based upon a determined tissue deformation.

Surgical navigation with stereovision and associated methods

An imaging system includes an illumination device for illuminating a target. A surgical microscope receives light from the target, the surgical microscope comprising at least one optical output port at which at least a portion of the received light is provided as an output from the surgical microscope. A tunable filter receives the portion of the received light provided as the output from the surgical microscope, the tunable filter being tunable to pass a filtered portion of the received light, the filtered portion of the received light having a plurality of wavelengths selected by the tunable filter and provided as output from the tunable filter. A high-resolution, broad-bandwidth electronic camera receives the light of a plurality of wavelengths selected by the tunable filter, the electronic camera converting the light of a plurality of wavelengths selected by the tunable filter to a plurality of electrical signals. A processor processes the plurality of electrical signals to form an image of the target.

Method and apparatus for quantitative hyperspectral fluorescence and reflectance imaging for surgical guidance

A method and device for determining the depth and fluorophore concentration of a fluorophore concentration below the surface of an optically absorbing and scattering medium suitable for use in fluorescence-based surgical guidance such as in tumor resection is described. Long-wavelength stimulus light us used to obtain deep tissue penetration. Recovery of depth is performed by fitting measured modulation amplitudes for each spatial frequency to precomputed modulation amplitudes in a table of modulation amplitudes indexed by optical parameters and depth.

Device and method for determining the depth of a subsurface fluorescent object within an optically absorbing and scattering medium and for determining concentration of fluorophore of the object

A method for guiding resection of local tissue from a patient includes generating at least one image of the patient, automatically determining a plurality of surgical guidance cues indicating three-dimensional spatial properties associated with the local tissue, and generating a visualization of the surgical guidance cues relative to the surface. A system for generating surgical guidance cues for resection of a local tissue from a patient includes a location module for processing at least one image of the patient to determine three-dimensional spatial properties of the local tissue, and a surgical cue generator for generating the surgical guidance cues based upon the three-dimensional spatial properties. A patient-specific locator form for guiding resection of local tissue from a patient includes a locator form surface matching surface of the patient, and a plurality of features indicating a plurality of surgical guidance cues, respectively.

An imaging system, such as a surgical microscope, laparoscope, or endoscope or integrated with these devices, includes an illuminator providing patterned white light and/or fluorescent stimulus light. The system receives and images light hyperspectrally, in embodiments using a hyperspectral imaging array, and/or using narrowband tunable filters for passing filtered received light to an imager. Embodiments may construct a 3-D surface model from stereo images, and will estimate optical properties of the target using images taken in patterned light or using other approximations obtained from white light exposures. Hyperspectral images taken under stimulus light are displayed as fluorescent images, and corrected for optical properties of tissue to provide quantitative maps of fluorophore concentration. Spectral information from hyperspectral images is processed to provide depth of fluorophore below the tissue surface. Quantitative images of fluorescence at depth are also prepared. The images are displayed to a surgeon for use in surgery.

Method and apparatus for quantitative and depth resolved hyperspectral fluorescence and reflectance imaging for surgical guidance

A method for determining sub-diffuse scattering parameters of a material includes illuminating the material with structured light and imaging remission by the material of the structured light. The method further includes determining, from captured remission images, sub-diffuse scattering parameters of the material. A structured-light imaging system for determining sub-diffuse scattering parameters of a material includes a structured-light illuminator, for illuminating the material with structured light of periodic spatial structure, and a camera for capturing images of the remission of the structured light by the material. The structured-light imaging system further includes an analysis module for processing the images to quantitatively determine the sub-diffuse scattering parameters. A software product includes machine-readable instructions for analyzing images of remission of structured light by a material to determine sub-diffuse scattering parameters of the material.

Structured-light imaging systems and methods for determining sub-diffuse scattering parameters

Device and method for determining depth and concentration of a subsurface fluorescent object

Growing community of inventors

Hanover, NH, United States of America

Keith Douglas Paulsen